Diabetes/Dementia in Sub-Saharian Africa and Nigerian Women in the Eye of Storm.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Efosa K Oghagbon, José Prieto-Pino, Faeren Dogoh, Monday Ogiator, Lydia Giménez-Llort
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引用次数: 1

Abstract

In the next few years, the prevalence of diabetes mellitus (DM) is projected to dramatically increase globally, but most of the cases will occur in low-to-middle-income countries. Some of the major risk factors for diabetes accelerate the development of dementia in African-Americans, thus leading to a higher prevalence of dementia than Caucasians. Sub-Saharian Africa women have a disproportionately two-to-eight fold increased prevalence of dementia. In the eye of this storm, Nigeria holds the highest number of diabetics on the African continent, and its prevalence is rising in parallel to obesity, hypertension, and the population's aging. The socio-economic impact of the rising prevalence of DM and dementia will be huge and unsustainable for the healthcare system in Nigeria, as has been recognized in developed economies. Here, we analyze the current situation of women's health in Nigeria and explore future perspectives and directions. The complex interplay of factors involved in diabetes and dementia in Nigerian women include key biological agents (metabolic syndrome, vascular damage, inflammation, oxidative stress, insulin resistance), nutritional habits, lifestyle, and anemia, that worsen with comorbidities. In addition, restricted resources, lack of visibility, and poor management result in a painful chain that increases the risk and burden of disease in Nigerian women from youth to old ages. Heath policies to increase the ratio of mental health professionals per number of patients, mostly in rural areas, foment of proactive primary care centers, and interventions targeting adolescents and adult women and other specific mothers-children pairs are strongly required for a sustainable development goal.

撒哈拉以南非洲的糖尿病/痴呆症和暴风眼中的尼日利亚妇女。
在未来几年中,糖尿病(DM)的患病率预计将在全球急剧增加,但大多数病例将发生在低收入和中等收入国家。糖尿病的一些主要危险因素加速了非裔美国人痴呆症的发展,因此导致痴呆症的患病率高于白种人。撒哈拉以南非洲地区的妇女患痴呆症的比例增加了2至8倍。在这场风暴的中心,尼日利亚是非洲大陆糖尿病患者人数最多的国家,其患病率与肥胖、高血压和人口老龄化同步上升。正如发达经济体所认识到的那样,糖尿病和痴呆症患病率上升对尼日利亚的医疗保健系统将产生巨大且不可持续的社会经济影响。在这里,我们分析了尼日利亚妇女健康的现状,并探讨了未来的前景和方向。尼日利亚妇女糖尿病和痴呆相关因素的复杂相互作用包括关键的生物因素(代谢综合征、血管损伤、炎症、氧化应激、胰岛素抵抗)、营养习惯、生活方式和贫血,这些因素随着合并症而恶化。此外,资源有限、缺乏能见度和管理不善造成了一个痛苦的链条,增加了尼日利亚妇女从青年到老年的疾病风险和负担。为实现可持续发展目标,迫切需要制定保健政策,提高精神卫生专业人员与患者(主要在农村地区)的比例,建立积极主动的初级保健中心,并针对青少年和成年妇女以及其他特定的母子对采取干预措施。
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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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