Transient Receptor Potential channels: A Global Bibliometric analysis From 2012 to 2021.

Abstract

The transient receptor potential (TRP) channels, nonselective ion channels, mediate the fluxes of various types of cations across the cell membrane such as Na+, K+, Mg2+, and Ca2 + . TRPA (Ankyrin), TRPC (Canonical), TRPM (Melastatin), TRPV (Vanilloid), TRPP (Polycystin), and TRPML (Mucolipin) are TRP major families members. These channels play essential roles in diverse physiologic processes, and participate in virtually every sensory modality. TRPs can be activated by chemicals, temperature, stretch/pressure, osmolarity, pH, and so on, and play a major role in the five primary senses, such as vision, taste, hearing, smell, and touch. In recent years, TRP channels are widely studied in the field of nervous, intestinal, renal, urogenital, respiratory, and cardiovascular systems in diverse therapeutic areas including pain and itch, headache, pulmonary function, oncology, neurology, visceral organs, and genetic diseases [1]. Bibliometric analysis has been widely used to calculate the productivity of countries, institutions, authors, and the frequency of keywords to explore research hotspots/frontiers in specific fields [2–4]. In the present study, we performed a bibliometric analysis to systematically evaluate the TRP channels studies from 2012 to 2021 by CiteSpace and VOSviewer to provide researchers with some direction regarding TRP channels research [5,6]. Data source and search