Left ventricular function and cardiac valvar annular dimensions among children with sickle cell anemia compared to those with hemoglobin AA type in Enugu, Nigeria.

IF 1.2 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Josephat M Chinawa, Awore T Chinawa, Edmund N Ossai, Bartholomew F Chukwu, Ikenna K Ndu, Isaac N Asinobi
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引用次数: 1

Abstract

Background: Enumerating the relationship between cardiac structures, function and chamber sizes in children with sickle cell anemia would help in delineating some cardiovascular abnormalities which will aid the Pediatric cardiologist and the cardiac surgeons in a number of decision-making situations.

Objectives: The objectives of this study are to assess the dimension of cardiac structures and left ventricular function in children with sickle cell anemia in steady state and controls using echocardiography.

Methods: A cross-sectional prospective study that assessed cardiac structures and left ventricular function among fifty-one children with sickle cell anemia (HBSS) and compared with fifty children with HB AA type serving as controls.

Results: A significant high proportion of children with sickle cell anemia had abnormal Valvar dimension and left ventricular function above two standard deviations (2-SD) from the mean of the standard population compared to the control group, showing a statistically significant difference (χ2 = 10.42, p= 0.001).All the mean annular valves diameter, left ventricular internal dimension in systole and diastole, inter-sinus distance diameter and sinu-tubular junction diameter are higher in children with sickle cell anemia than controls and this is statistically significant. (p<0.005).

Conclusion: This result shows that children with sickle cell anemia have increased valvar size diameter compared with those with normal hemoglobin type. A significantly higher proportion of respondents in type SS group had abnormal left ventricular systolic and diastolic dysfunction when compared with those in type AA group.

尼日利亚埃努古镰状细胞性贫血儿童与AA型血红蛋白儿童左心室功能和心脏瓣膜环尺寸的比较
背景:列举镰状细胞性贫血儿童心脏结构、功能和腔室大小之间的关系有助于描述一些心血管异常,这将有助于儿科心脏病专家和心脏外科医生在许多决策情况下。目的:本研究的目的是利用超声心动图评估镰状细胞性贫血儿童在稳定状态和对照组的心脏结构和左心室功能的尺寸。方法:一项横断面前瞻性研究评估了51名镰状细胞性贫血(HBSS)儿童的心脏结构和左心室功能,并与50名HB AA型儿童作为对照。结果:镰状细胞性贫血患儿瓣膜尺寸和左心室功能异常高于标准人群2个标准差(2-SD)的比例显著高于对照组,差异有统计学意义(χ2 = 10.42, p= 0.001)。镰状细胞性贫血患儿环瓣平均直径、左室收缩期和舒张期内径、窦间距离直径和窦管结直径均高于对照组,差异有统计学意义。结论:镰状细胞性贫血患儿瓣膜直径较血红蛋白正常型患儿增大。与AA型组相比,SS型组左室收缩和舒张功能异常的比例明显高于AA型组。
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来源期刊
Malawi Medical Journal
Malawi Medical Journal Medicine-General Medicine
CiteScore
1.50
自引率
0.00%
发文量
27
审稿时长
>12 weeks
期刊介绍: Driven and guided by the priorities articulated in the Malawi National Health Research Agenda, the Malawi Medical Journal publishes original research, short reports, case reports, viewpoints, insightful editorials and commentaries that are of high quality, informative and applicable to the Malawian and sub-Saharan Africa regions. Our particular interest is to publish evidence-based research that impacts and informs national health policies and medical practice in Malawi and the broader region. Topics covered in the journal include, but are not limited to: - Communicable diseases (HIV and AIDS, Malaria, TB, etc.) - Non-communicable diseases (Cardiovascular diseases, cancer, diabetes, etc.) - Sexual and Reproductive Health (Adolescent health, education, pregnancy and abortion, STDs and HIV and AIDS, etc.) - Mental health - Environmental health - Nutrition - Health systems and health policy (Leadership, ethics, and governance) - Community systems strengthening research - Injury, trauma, and surgical disorders
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