miR-938rs2505901 T>C polymorphism increases Hirschsprung disease risk: a case-control study of Chinese children.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-09-01 Epub Date: 2021-11-11 DOI:10.2217/pme-2021-0001

Jun Zhong, Jiabin Liu, Yi Zheng, Xiaoli Xie, Qiuming He, Wei Zhong, Qiang Wu

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引用次数: 1

Abstract

Aim: To explore the association between miR-938rs2505901 T>C polymorphism and Hirschsprung disease (HSCR) risk in Chinese children. Materials & Methods: We conducted a case-control study in a Chinese population with 1381 cases and 1457 controls. The associated correlation strengths were assessed by adjusted odds ratios (AORs) and 95% CIs. Results: The results revealed that the rs2505901 TC and rs2505901 TC/CC genotype were related to an increased HSCR risk compared to the risk contributed by the rs2505901 TT genotype. A stratification analysis showed that the rs2505901 TC/CC genotype promoted the progression of HSCR more significantly in patients with the short-segment HSCR subtype. Conclusion: Our study indicated that miR-938rs2505901 T>C polymorphism is significantly associated with HSCR risk in Chinese children. This result needs to be confirmed with well-designed studies.

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miR-938rs2505901 T>C多态性增加先天性巨结肠疾病风险:一项中国儿童病例对照研究

目的:探讨miR-938rs2505901 T>C多态性与中国儿童先天性巨结肠病(HSCR)风险的关系。材料与方法:我们在中国人群中进行了一项病例对照研究，共有1381例病例和1457例对照。通过校正优势比(AORs)和95% ci评估相关强度。结果:结果显示，与rs2505901 TT基因型相比，rs2505901 TC和rs2505901 TC/CC基因型与HSCR风险增加相关。分层分析显示，rs2505901 TC/CC基因型在短段HSCR亚型患者中更显著地促进HSCR的进展。结论:我们的研究表明miR-938rs2505901 T>C多态性与中国儿童HSCR风险显著相关。这一结果需要通过精心设计的研究来证实。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.