miR-938rs2505901 T>C polymorphism increases Hirschsprung disease risk: a case-control study of Chinese children.

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Personalized medicine Pub Date : 2021-09-01 Epub Date: 2021-11-11 DOI:10.2217/pme-2021-0001
Jun Zhong, Jiabin Liu, Yi Zheng, Xiaoli Xie, Qiuming He, Wei Zhong, Qiang Wu
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引用次数: 1

Abstract

Aim: To explore the association between miR-938rs2505901 T>C polymorphism and Hirschsprung disease (HSCR) risk in Chinese children. Materials & Methods: We conducted a case-control study in a Chinese population with 1381 cases and 1457 controls. The associated correlation strengths were assessed by adjusted odds ratios (AORs) and 95% CIs. Results: The results revealed that the rs2505901 TC and rs2505901 TC/CC genotype were related to an increased HSCR risk compared to the risk contributed by the rs2505901 TT genotype. A stratification analysis showed that the rs2505901 TC/CC genotype promoted the progression of HSCR more significantly in patients with the short-segment HSCR subtype. Conclusion: Our study indicated that miR-938rs2505901 T>C polymorphism is significantly associated with HSCR risk in Chinese children. This result needs to be confirmed with well-designed studies.

miR-938rs2505901 T>C多态性增加先天性巨结肠疾病风险:一项中国儿童病例对照研究
目的:探讨miR-938rs2505901 T>C多态性与中国儿童先天性巨结肠病(HSCR)风险的关系。材料与方法:我们在中国人群中进行了一项病例对照研究,共有1381例病例和1457例对照。通过校正优势比(AORs)和95% ci评估相关强度。结果:结果显示,与rs2505901 TT基因型相比,rs2505901 TC和rs2505901 TC/CC基因型与HSCR风险增加相关。分层分析显示,rs2505901 TC/CC基因型在短段HSCR亚型患者中更显著地促进HSCR的进展。结论:我们的研究表明miR-938rs2505901 T>C多态性与中国儿童HSCR风险显著相关。这一结果需要通过精心设计的研究来证实。
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来源期刊
Personalized medicine
Personalized medicine 医学-药学
CiteScore
3.30
自引率
4.30%
发文量
49
审稿时长
6-12 weeks
期刊介绍: Personalized Medicine (ISSN 1741-0541) translates recent genomic, genetic and proteomic advances into the clinical context. The journal provides an integrated forum for all players involved - academic and clinical researchers, pharmaceutical companies, regulatory authorities, healthcare management organizations, patient organizations and others in the healthcare community. Personalized Medicine assists these parties to shape thefuture of medicine by providing a platform for expert commentary and analysis. The journal addresses scientific, commercial and policy issues in the field of precision medicine and includes news and views, current awareness regarding new biomarkers, concise commentary and analysis, reports from the conference circuit and full review articles.
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