Molecular mechanisms and roles of inflammatory responses on low-frequency residual hearing after cochlear implantation

IF 1.4 Q2 OTORHINOLARYNGOLOGY
Juanjuan Gao, Haijin Yi
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引用次数: 2

Abstract

Preservation of low-frequency residual hearing is very important for combined electro-acoustic stimulation after cochlear implantation. However, in clinical practice, loss of low-frequency residual hearing often occurs after cochlear implantation and its mechanisms remain unclear. Factors affecting low-frequency residual hearing after cochlear implantation are one of the hot spots in current research. Inflammation induced by injury associated with cochlear implantation is deemed to be significant, as it may give rise to low-frequency residual hearing loss by interfering with the blood labyrinth barrier and neural synapses. Pathological changes along the pathway for low-frequency auditory signals transmission may include latent factors such as damage to neuroepithelial structures, synapses, stria vascularis and other ultrastructures. In this review, current research on mechanisms of low-frequency residual hearing loss after cochlear implantation and possible roles of inflammatory responses are summarized.

人工耳蜗植入后低频残余听力炎症反应的分子机制及作用
在人工耳蜗植入后的电声联合刺激中,低频残听的保存是非常重要的。然而在临床实践中,人工耳蜗植入后经常出现低频残余听力丧失,其机制尚不清楚。影响人工耳蜗植入后低频残余听力的因素是目前研究的热点之一。人工耳蜗植入损伤引起的炎症被认为是重要的,因为它可能通过干扰血迷宫屏障和神经突触而引起低频残余听力损失。低频听觉信号传递通路的病理改变可能包括神经上皮结构、突触、血管纹等超微结构的损伤等潜在因素。本文就人工耳蜗植入后低频残余听力损失的机制及炎症反应可能在其中的作用进行综述。
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来源期刊
Journal of Otology
Journal of Otology Medicine-Otorhinolaryngology
CiteScore
2.70
自引率
0.00%
发文量
461
审稿时长
18 days
期刊介绍: Journal of Otology is an open access, peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear. This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with disorders of the auditory and vestibular systems. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines. Journal of Otology welcomes contributions from scholars in all countries and regions across the world.
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