The a' velocity by tissue-Doppler echocardiography correlates to invasive mean left atrial pressure in patients with normal ejection fraction.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-12-01 Epub Date: 2022-02-09 DOI:10.1080/14017431.2022.2032317

Benny Johansson, Espen Fengsrud, Fredrik Lundin, Leif Bojö, Dritan Poci

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引用次数: 1

Abstract

Objectives: To evaluate the correlation of a' velocity by tissue-Doppler measurements with invasively measured mean left atrial pressure in patients with normal ejection fraction.

Design: In this retrospective study, we evaluated the septal a', lateral a' and average a' velocity by tissue-Doppler echocardiography, in 125 in-hospital patients, 1-12 h before an elective pulmonary vein isolation due to intermittent atrial fibrillation, and compared to invasively measured mean left atrial pressure (LAP) during the invasive procedure. The patients, aged 35-81 years, had to be in sinus rhythm at both examinations, no atrial fibrillation during two procedures, no or mild valve disease and normal ejection fraction (>50%).

Results: Invasively measured mean LAP correlated well to septal a' (r = -0.435), lateral a' (r = -0.473) and average a' velocity (r = -0.491). Normal mean LAP (≤12 mmHg) was found in 95 patients and elevated mean LAP (>12 mmHg) in 30 patients. The patients with elevated mean LAP had a lower septal a' velocity (6.5 ± 2.7 vs 8.6 ± 2.3 cm/s; p < .01), lateral a' velocity (5.9 ± 2.3 vs 8.6 ± 2.1 cm/s; p < .01) and average a' velocity (6.2 ± 2.4 vs 8.8 ± 2.1 cm/s; p < .01) compared to patients with normal mean LAP. Septal a', lateral a' and average a' velocity were good predictors of elevated mean LAP with AUC of 0.78, 0.83 and 0.82. Average a' velocity with cut-off < 7.25 cm/s had a sensitivity of 83% and a specificity of 77% to predict elevated mean LAP.

Conclusion: The a' velocity is a good indicator of mean LAP and might be considered in the evaluation of left ventricle filling pressure in patients with normal ejection fraction.

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在射血分数正常的情况下，组织多普勒超声心动图a′速度与有创平均左房压相关。

目的:探讨在射血分数正常的情况下，组织多普勒血流速度与有创左房压的相关性。设计:在这项回顾性研究中，我们通过组织多普勒超声心动图评估了125例因间歇性房颤而进行选择性肺静脉隔离前1-12小时住院患者的室间隔a′、侧a′和平均a′速度，并与有创手术期间测量的平均左房压(LAP)进行了比较。患者年龄35-81岁，两次检查均处于窦性心律，两次手术均无房颤，无或轻度瓣膜疾病，射血分数正常(>50%)。结果:有创测量的平均LAP与中隔a′(r = -0.435)、侧位a′(r = -0.473)和平均a′速度(r = -0.491)相关良好。95例患者平均LAP正常(≤12 mmHg)， 30例患者平均LAP升高(>12 mmHg)。平均LAP升高的患者中隔流速较低(6.5±2.7 vs 8.6±2.3 cm/s);p < . 01),横向速度(5.9±2.3 vs 8.6±2.1厘米/秒;P < 0.01)，平均流速(6.2±2.4 vs 8.8±2.1 cm/s);p < 0.01)。间隔a′、侧a′和平均a′速度是平均LAP升高的良好预测因子，AUC分别为0.78、0.83和0.82。截止值< 7.25 cm/s的平均流速预测平均LAP升高的敏感性为83%，特异性为77%。结论:a′流速是衡量平均LAP的良好指标，可作为评价射血分数正常患者左室充盈压力的参考指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.