[Charged Particle Therapy Technologies Originated in Japan].

Toshiyuki Shirai
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Abstract

A charged particle therapy was proposed by Robert R. Wilson in 1946 and a clinical study of proton radiotherapy had been started at Lawrence Berkeley National Laboratory in 1954. Clinical studies have been promoted mainly in the United States and Europe. However, in Japan as well, the University of Tsukuba (KEK Campus) and the National Institute of Radiological Sciences (NIRS) started proton radiotherapy around 1980, and NIRS started carbon-ion radiotherapy in 1994. Following pioneering clinical studies, now in Japan, many proton and carbon-ion radiotherapy facilities are in operation, and some vendors are supplying equipment. Among them, charged particle therapy technologies originating in Japan have been developed, such as a respiratory-gated irradiation technology, a spot scanning irradiation technology, and a clinical dose design for ion radiotherapy. I look back on them and discuss the future direction of research and development of the charged particle therapy.

[带电粒子治疗技术起源于日本]。
1946年,罗伯特·r·威尔逊提出了一种带电粒子疗法,1954年,劳伦斯伯克利国家实验室开始了质子放疗的临床研究。临床研究主要在美国和欧洲得到推广。然而,在日本,筑波大学(KEK校区)和国立放射科学研究所(NIRS)在1980年左右开始了质子放疗,NIRS在1994年开始了碳离子放疗。在开创性的临床研究之后,现在在日本,许多质子和碳离子放射治疗设施正在运行,一些供应商正在提供设备。其中,开发了源于日本的带电粒子治疗技术,如呼吸门控照射技术、点扫描照射技术、离子放疗临床剂量设计等。我对它们进行了回顾,并讨论了未来带电粒子治疗的研究和发展方向。
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