LRRK2 signaling in neurodegeneration: two decades of progress.

IF 5.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Essays in biochemistry Pub Date : 2021-12-22 DOI:10.1042/EBC20210013

Lucia Iannotta, Elisa Greggio

引用次数: 3

Abstract

Leucine-rich repeat kinase 2 (LRRK2) is a complex GTPase/kinase orchestrating cytoskeletal dynamics and multiple steps of the endolysosomal pathway through interaction with a host of partners and phosphorylation of a subset of Rab GTPases. Mutations in LRRK2 cause late-onset Parkinson's disease (PD) and common variants in the locus containing LRRK2 have been associated with sporadic PD, progressive supranuclear palsy as well as a number of inflammatory diseases. This review encompasses the major discoveries in the field of LRRK2 pathobiology, from the initial gene cloning to the latest progress in LRRK2 inhibition as a promising therapeutic approach to fight neurodegeneration.

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LRRK2信号在神经退行性变中的作用:二十年的进展。

富亮氨酸重复激酶2 (LRRK2)是一种复杂的GTPase/激酶，通过与大量伙伴的相互作用和Rab GTPase亚群的磷酸化，协调细胞骨架动力学和内溶酶体途径的多个步骤。LRRK2突变导致晚发性帕金森病(PD)，含有LRRK2基因座的常见变异与散发性PD、进行性核上性麻痹以及许多炎症性疾病有关。本文综述了LRRK2病理生物学领域的重大发现，从最初的基因克隆到LRRK2抑制作为一种有希望的治疗神经退行性疾病的方法的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Essays in biochemistry 生物-生化与分子生物学

CiteScore

10.50

自引率

0.00%

发文量

105

审稿时长

>12 weeks

期刊介绍： Essays in Biochemistry publishes short, digestible reviews from experts highlighting recent key topics in biochemistry and the molecular biosciences. Written to be accessible for those not yet immersed in the subject, each article is an up-to-date, self-contained summary of the topic. Bridging the gap between the latest research and established textbooks, Essays in Biochemistry will tell you what you need to know to begin exploring the field, as each article includes the top take-home messages as summary points. Each issue of the journal is guest edited by a key opinion leader in the area, and whether you are continuing your studies or moving into a new research area, the Journal gives a complete picture in one place. Essays in Biochemistry is proud to publish Understanding Biochemistry, an essential online resource for post-16 students, teachers and undergraduates. Providing up-to-date overviews of key concepts in biochemistry and the molecular biosciences, the Understanding Biochemistry issues of Essays in Biochemistry are published annually in October.