Can harmful lifestyle, obesity and weight changes increase the risk of breast cancer in BRCA 1 and BRCA 2 mutation carriers? A Mini review.

IF 2 4区医学 Q3 ONCOLOGY

Hereditary Cancer in Clinical Practice Pub Date : 2021-10-27 DOI:10.1186/s13053-021-00199-6

A Daniele, R Divella, B Pilato, S Tommasi, P Pasanisi, M Patruno, M Digennaro, C Minoia, M Dellino, S Pisconti, P Casamassima, E Savino, A V Paradiso

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引用次数: 19

Abstract

Background and aim: The BRCA 1 and BRCA 2 genes are associated with an inherited susceptibility to breast cancer with a cumulative risk of 60% in BRCA 1 mutation carriers and of 30% in BRCA 2 mutation carriers. Several lifestyle factors could play a role in determining an individual's risk of breast cancer. Obesity, changes in body size or unhealthy lifestyle habits such as smoking, alcohol consumption and physical inactivity have been evaluated as possible determinants of breast cancer risk. The aim of this study was to explore the current understanding of the role of harmful lifestyle and obesity or weight change in the development of breast cancer in female carriers of BRCA 1/2 mutations.

Methods: Articles were identified from MEDLINE in October 2020 utilizing related keywords; they were then read and notes, study participants, measures, data analysis and results were used to write this review.

Results: Studies with very large case series have been carried out but only few of them have shown consistent results. Additional research would be beneficial to better determine the actual role and impact of such factors.

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有害的生活方式、肥胖和体重变化会增加BRCA 1和BRCA 2突变携带者患乳腺癌的风险吗?一个小评论。

背景和目的:BRCA 1和BRCA 2基因与乳腺癌的遗传易感性相关，BRCA 1突变携带者的累积风险为60%，BRCA 2突变携带者的累积风险为30%。一些生活方式因素可能在决定一个人患乳腺癌的风险方面发挥作用。肥胖、体型变化或不健康的生活习惯，如吸烟、饮酒和缺乏体育活动，已被评估为乳腺癌风险的可能决定因素。本研究的目的是探讨目前对BRCA 1/2突变女性携带者中有害生活方式和肥胖或体重变化在乳腺癌发展中的作用的理解。方法:利用相关关键词从MEDLINE检索2020年10月的文章;然后阅读它们，并使用笔记、研究参与者、测量、数据分析和结果来撰写这篇综述。结果:已经进行了大量病例的研究，但只有少数显示出一致的结果。进一步的研究将有助于更好地确定这些因素的实际作用和影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hereditary Cancer in Clinical Practice 医学-肿瘤学

CiteScore

3.10

自引率

5.90%

发文量

审稿时长

>12 weeks

期刊介绍： Hereditary Cancer in Clinical Practice is an open access journal that publishes articles of interest for the cancer genetics community and serves as a discussion forum for the development appropriate healthcare strategies. Cancer genetics encompasses a wide variety of disciplines and knowledge in the field is rapidly growing, especially as the amount of information linking genetic differences to inherited cancer predispositions continues expanding. With the increased knowledge of genetic variability and how this relates to cancer risk there is a growing demand not only to disseminate this information into clinical practice but also to enable competent debate concerning how such information is managed and what it implies for patient care. Topics covered by the journal include but are not limited to: Original research articles on any aspect of inherited predispositions to cancer. Reviews of inherited cancer predispositions. Application of molecular and cytogenetic analysis to clinical decision making. Clinical aspects of the management of hereditary cancers. Genetic counselling issues associated with cancer genetics. The role of registries in improving health care of patients with an inherited predisposition to cancer.