Tiago de Castro, Christoph Beier, Christoph Terkamp, Lucia Oehler, Bernhard M W Schmidt, Johannes Heck, Dirk Stichtenoth, Heiner Wedemeyer, Holger Leitolf
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引用次数: 2
Abstract
A 69-year-old female patient was referred to the Medical University of Hanover for further diagnostic evaluation of recurrent severe hypoglycemia. The patient had previously been started on clopidogrel after arterial stenting for peripheral arterial obstructive disease (PAOD). The presence of an insulinoma and paraneoplastic syndrome was excluded. Increased serum insulin and insulin autoantibodies levels were confirmed, despite normal to low blood sugar levels. An insulin autoimmune syndrome was diagnosed, most likely induced by the prior intake of clopidogrel. Treatment with immunoadsorption was initiated, achieving a significant reduction in hypoglycemic events and a lasting response to treatment over 3 months.
期刊介绍：
Der Internist is an internationally respected journal dealing with all aspects of internal medicine. The journal serves both the scientific exchange and the continuing education of internists working in practical or clinical environments as well as of general practitioners who are particularly interested in internal medicine. The focus is on the topics of prevention, diagnostic approaches, management of complications, and current therapy strategies.
Comprehensive reviews on a specific topical issue focus on providing evidenced based information on diagnostics and therapy.
Case reports feature interesting cases and aim at optimizing diagnostic and therapeutic strategies.
Review articles under the rubric "Continuing Medical Education" present verified results of scientific research and their integration into daily practice.
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