Investigating the Factors Associated with the Level of Expression of Estrogen and Progesterone Receptors in Patients Suffering from Colorectal Cancer.

IF 1.8 Q3 ONCOLOGY

Journal of Cancer Epidemiology Pub Date : 2021-10-15 eCollection Date: 2021-01-01 DOI:10.1155/2021/4478155

Saleheh Salehi Far, Maryam Soltani, Mahmoud Zardast, Mohammad Reza Ghasemian Moghaddam

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引用次数: 4

Abstract

Background: The present study was performed to investigate the factors related to the expression level of estrogen and progesterone receptor in patients with colorectal cancer. Material and Methods. This crosssectional study was performed on 54 patients suffering from colorectal cancer referring to Imam Reza Hospital in Birjand during 2018-2019. After the biopsy performed during surgery, the specimen was sent for immunohistochemistry, and the status of receptors was determined. Eventually, the data were analyzed by SPSS 22.

Results: Out of the 54 patients studied, 64.8% were male. The mean age of the patients was 62.28 ± 14.03 years. The level of expression of beta-estrogen receptors and progesterone receptors had a significant relationship with age, consuming drugs of abuse, and familial history (P = 0.001). Also, the level of expression of estrogen and progesterone receptors of patients with a more advanced stage of cancer was significantly lower (P = 0.001).

Conclusion: The extent of expression of estrogen and progesterone receptors affects the progression and prognosis of disease. Thus, through hormone therapy, a step can be taken to reduce the progression and even to treat colorectal cancer.

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结直肠癌患者雌激素和孕激素受体表达水平的相关因素研究。

背景:本研究旨在探讨影响结直肠癌患者雌激素和孕激素受体表达水平的相关因素。材料和方法。这项横断面研究是在2018-2019年期间在印度比哈尔德邦伊玛目礼萨医院就诊的54名结直肠癌患者中进行的。手术中进行活检后，标本送免疫组织化学，并确定受体的状态。最后用SPSS 22对数据进行分析。结果:54例患者中，男性占64.8%。患者平均年龄62.28±14.03岁。β -雌激素受体和孕激素受体的表达水平与年龄、滥用药物史和家族史有显著关系(P = 0.001)。此外，晚期癌症患者的雌激素和孕激素受体表达水平显著降低(P = 0.001)。结论:雌激素和孕激素受体的表达程度影响疾病的进展和预后。因此，通过激素治疗，可以采取措施减少进展，甚至治疗结直肠癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cancer Epidemiology ONCOLOGY-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Journal of Cancer Epidemiology is a peer-reviewed, open access journal that publishes original research articles, review articles, case reports, and clinical studies in all areas of cancer epidemiology.