The Characteristics of Power Spectral Density in Bipolar Disorder at the Resting State.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Clinical EEG and Neuroscience Pub Date : 2023-11-01 Epub Date: 2021-10-22 DOI:10.1177/15500594211050487
Masakazu Sunaga, Yuichi Takei, Yutaka Kato, Minami Tagawa, Tomohiro Suto, Naruhito Hironaga, Noriko Sakurai, Masato Fukuda
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引用次数: 2

Abstract

Bipolar disorder (BD) is a common psychiatric disorder, but its pathophysiology is not fully elucidated. The current study focused on its electrophysiological characteristics, especially power spectral density (PSD). Resting state with eyes opened magnetoencephalography data were collected from 21 patients with BD and 22 healthy controls. The whole brain's PSD was calculated from source reconstructed waveforms at each frequency band (delta: 1-3 Hz, theta: 4-7 Hz, alpha: 8-12 Hz, low beta: 13-19 Hz, high beta: 20-29 Hz, and gamma: 30-80 Hz). We compared PSD values on the marked vertices at each frequency band between healthy and patient groups using a Mann-Whitney rank test to examine the relationship between significantly different PSD and clinical measures. The PSD in patients with BD was significantly decreased in lower frequency bands, mainly in the default mode network (DMN) areas (bilateral medial prefrontal cortex, bilateral precuneus, left inferior parietal lobe, and right temporal cortex in the alpha band) and salience network areas (SAL; left anterior insula [AI] at the delta band, anterior cingulate cortex at the theta band, and right AI at the alpha band). No significant differences in PSD were observed at low beta and high beta. PSD was not correlated with age or other clinical scales. Altered PSDs of the DMN and SAL were observed in the delta, theta, and alpha bands. These alterations contribute to the vulnerability of BD through the disturbance of self-referential mental activity and switching between the default mode and frontoparietal networks.

静息状态下双相情感障碍的功率谱密度特征。
双相情感障碍(BD)是一种常见的精神疾病,但其病理生理学尚未完全阐明。目前的研究主要集中在其电生理特性,特别是功率谱密度(PSD)方面。从21名BD患者和22名健康对照组中收集睁开眼睛的静息状态脑磁图数据。根据每个频带的源重构波形计算整个大脑的PSD(delta:1-3 Hz,θ:4-7 Hz,α:8-12 Hz,低β:13-19 Hz,高β:20-29 Hz,伽玛:30-80 Hz)。我们使用Mann-Whitney秩检验比较了健康组和患者组之间每个频带标记顶点上的PSD值,以检查显著不同的PSD与临床测量之间的关系。BD患者的PSD在低频段显著降低,主要在默认模式网络(DMN)区域(位于α带的双侧内侧前额叶皮层、双侧楔前叶、左下顶叶和右颞叶皮层)和显著性网络区域(SAL;位于δ带的左前脑岛[AI]、位于θ带的前扣带皮层和位于α带上的右AI)。在低β和高β时未观察到PSD的显著差异。PSD与年龄或其他临床量表无关。在δ、θ和α带中观察到DMN和SAL的PSD改变。这些改变通过干扰自我参照的心理活动以及在默认模式和额顶顶网络之间切换,导致BD的脆弱性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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