The Utility of Chest Imaging for Surveillance of Atypical Lipomatous Tumors.

Q2 Medicine

Sarcoma Pub Date : 2021-10-11 eCollection Date: 2021-01-01 DOI:10.1155/2021/4740924

Alexander L Lazarides, Harrison R Ferlauto, Zachary D C Burke, Anthony M Griffin, Bruce D Leckey, Nicholas M Bernthal, Jay S Wunder, Peter C Ferguson, Julia D Visgauss, Brian E Brigman, William C Eward

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引用次数: 4

Abstract

Background: Unlike other soft tissue sarcomas, atypical lipomatous tumors (ALTs) are thought to have a low propensity for metastasis. Despite this, a standard of care for pulmonary metastasis (PM) surveillance has not been established. This study aimed to evaluate the utility of chest imaging for PM surveillance following ALT excision.

Methods: This was a multi-institution, retrospective review of all patients with primary ALTs of the extremities or superficial torso who underwent excision between 2006 and 2018. Minimum follow-up was two years. Long-term survival was evaluated using the Kaplan-Meier method.

Results: 190 patients with ALT were included. Average age was 61.7 years and average follow-up was 58.6 months (24 to 180 months). MDM2 testing was positive in 88 patients (46.3%), and 102 (53.7%) did not receive MDM2 testing. 188 patients (98.9%) had marginal excision, and 127 (66.8%) had marginal or positive margins. Patients received an average of 0.9 CT scans and 1.3 chest radiographs over the surveillance period. 10-year metastasis-free survival was 100%, with no documented deaths from disease.

Conclusions: This study suggests that chest imaging does not have a significant role in PM surveillance following ALT excision, but advanced local imaging and chest surveillance may be considered in cases of local recurrence or concern for dedifferentiation.

Abstract Image

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胸部影像学在非典型脂肪瘤监测中的应用。

背景:与其他软组织肉瘤不同，非典型脂肪瘤(ALTs)被认为具有低转移倾向。尽管如此，肺转移(PM)监测的护理标准尚未建立。本研究旨在评估ALT切除后胸部成像对PM监测的效用。方法:这是一项多机构的回顾性研究，纳入了2006年至2018年期间接受手术切除的所有四肢或躯干浅表原发alt患者。最低随访时间为两年。采用Kaplan-Meier法评估长期生存率。结果:纳入190例ALT患者。平均年龄61.7岁，平均随访时间58.6个月(24 ~ 180个月)。88例(46.3%)MDM2检测阳性，102例(53.7%)未接受MDM2检测。188例(98.9%)边缘切除，127例(66.8%)边缘或阳性切缘。在监测期间，患者平均接受了0.9次CT扫描和1.3次胸片检查。10年无转移生存率为100%，无疾病死亡记录。结论:本研究提示，在ALT切除后的PM监测中，胸部成像没有显著作用，但在局部复发或担心去分化的情况下，可以考虑进行先进的局部成像和胸部监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sarcoma Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Sarcoma is dedicated to publishing papers covering all aspects of connective tissue oncology research. It brings together work from scientists and clinicians carrying out a broad range of research in this field, including the basic sciences, molecular biology and pathology and the clinical sciences of epidemiology, surgery, radiotherapy and chemotherapy. High-quality papers concerning the entire range of bone and soft tissue sarcomas in both adults and children, including Kaposi"s sarcoma, are published as well as preclinical and animal studies. This journal provides a central forum for the description of advances in diagnosis, assessment and treatment of this rarely seen, but often mismanaged, group of patients.