Bone involvement in young adults with cystic fibrosis - a Portuguese cohort.

IF 1 4区医学 Q4 RHEUMATOLOGY

Acta reumatologica portuguesa Pub Date : 2021-07-01

Salomé Garcia, Georgina Terroso, Adelina Amorim, Margarida Redondo, Lúcia Costa

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引用次数: 0

Abstract

Introduction: Long-term survivors of cystic fibrosis (CF) have a dramatic increase in the risk of osteoporosis and incident fracture. The objective of this work is to characterize a CF related bone disease in a Portuguese cohort of CF patients.

Methods: We performed a cross-sectional, observational study on a cohort of CF adult patients. Clinical status, laboratory parametres, nutrition, lung function tests, genetics and bone mineral density (BMD) data were collected from a CF reference centre.

Results: Of 30 patients, 53.3% were males (n=16). Median age was 32.5 (27.0; 32,5) and median body mass index (BMI) was 22,04 (19,85; 24,55), with 4 patients (13.3%) being underweight (BMI<18.5 kg/m²). Four patients (13.3 %) were diagnosed with osteoporosis and 15 patients (50%) has low BMD. Among them, 2 (6.7%) had fragility fractures. A moderate correlation was found between the lumbar spine (LS) BMD and BMI and, as expected, femural neck BMD and LS BMD has moderate to strong correlations with BMD Z scores.

Conclusion: Despite the young middle age we found a high prevalence of low BMD and osteoporosis in patients with CF. Early recognition and treatment are the most effective strategies for reducing the morbidity due to osteoporosis in these patients.

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患有囊性纤维化的年轻人的骨骼受累——一项葡萄牙队列研究。

囊性纤维化(CF)的长期幸存者发生骨质疏松和意外骨折的风险显著增加。本研究的目的是在葡萄牙CF患者队列中描述CF相关骨病的特征。方法:我们对一组成年CF患者进行了横断面观察性研究。临床状况、实验室参数、营养、肺功能测试、遗传学和骨密度(BMD)数据从CF参考中心收集。结果:30例患者中，男性16例，占53.3%。中位年龄32.5岁(27.0岁;32,5)，中位体重指数(BMI)为22,04 (19,85;24,55)， 4例患者(13.3%)体重过轻(bmic)。结论:尽管年龄处于中青年，但我们发现CF患者骨密度低和骨质疏松症的患病率很高。早期发现和治疗是降低这些患者骨质疏松症发病率的最有效策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta reumatologica portuguesa 医学-风湿病学

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Reumatólogica Portuguesa is a scientific peer reviewed journal covering all aspects of rheumatic diseases and related to Rheumatology. The journal publishes original articles, reviews, clinical cases, images in rheumatology, letters to the editor and clinical teaching (e.g. guidelines and clinical protocols). Published since 1973, Acta Reumatológica Portuguesa is the official scientific publication of the Portuguese Society of Rheumatology, a non-profit organization that promotes the knowledge and investigation of rheumatic diseases and the development of Rheumatology.