COVID-19 and Psychotic Symptoms: the View from Psychiatric Immunology.

IF 2.1 Q3 NEUROSCIENCES

Current Behavioral Neuroscience Reports Pub Date : 2021-01-01 Epub Date: 2021-10-04 DOI:10.1007/s40473-021-00235-8

Sarvodaya Tripathy, Nitika Singh, Amit Singh, Sujita Kumar Kar

{"title":"COVID-19 and Psychotic Symptoms: the View from Psychiatric Immunology.","authors":"Sarvodaya Tripathy, Nitika Singh, Amit Singh, Sujita Kumar Kar","doi":"10.1007/s40473-021-00235-8","DOIUrl":null,"url":null,"abstract":"Purpose of review: To explore the immunological underpinnings of psychosis in the COVID-19 patients.Recent findings: COVID-19 pandemic led to a surge in psychiatric morbidities, including psychosis. Various putative biological and psychosocial changes have been implicated in COVID-19-related psychosis. COVID-19 is a proinflammatory state. Alterations in immunological processes both as a direct consequence of infection or secondary to the hyperimmune response heuristically explain the etiopathogenesis of psychosis in the affected individual. The uses of immunosuppressant and immunomodulatory drugs may be the other moderators of a psychotic presentation in COVID-19 patients. Evidence to substantiate this hypothesis is still lacking however, which further studies should address. Because of its management implications, a better understanding of the involved immunological mechanisms becomes extremely important.Summary: Evidence suggests a putative role of immunological alterations in the pathogenesis of COVID-19-related psychosis. The immunological abnormalities are primarily attributed to the pathophysiology of COVID-19 infection, medications used, and stress.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":" ","pages":"172-178"},"PeriodicalIF":2.1000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487803/pdf/","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Behavioral Neuroscience Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40473-021-00235-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/10/4 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 9

Abstract

Purpose of review: To explore the immunological underpinnings of psychosis in the COVID-19 patients.

Recent findings: COVID-19 pandemic led to a surge in psychiatric morbidities, including psychosis. Various putative biological and psychosocial changes have been implicated in COVID-19-related psychosis. COVID-19 is a proinflammatory state. Alterations in immunological processes both as a direct consequence of infection or secondary to the hyperimmune response heuristically explain the etiopathogenesis of psychosis in the affected individual. The uses of immunosuppressant and immunomodulatory drugs may be the other moderators of a psychotic presentation in COVID-19 patients. Evidence to substantiate this hypothesis is still lacking however, which further studies should address. Because of its management implications, a better understanding of the involved immunological mechanisms becomes extremely important.

Summary: Evidence suggests a putative role of immunological alterations in the pathogenesis of COVID-19-related psychosis. The immunological abnormalities are primarily attributed to the pathophysiology of COVID-19 infection, medications used, and stress.

Abstract Image

查看原文本刊更多论文

COVID-19与精神病症状:来自精神免疫学的观点。

综述目的:探讨COVID-19患者精神病的免疫学基础。最新发现:COVID-19大流行导致包括精神病在内的精神疾病发病率激增。各种假定的生物和社会心理变化与covid -19相关精神病有关。COVID-19是一种促炎状态。作为感染的直接后果或继发于超免疫反应的免疫过程的改变启发式地解释了受影响个体精神病的发病机制。免疫抑制剂和免疫调节药物的使用可能是COVID-19患者精神病表现的其他调节因素。然而，证实这一假设的证据仍然缺乏，需要进一步的研究来解决。由于其管理意义，更好地了解所涉及的免疫机制变得极其重要。总结:有证据表明，免疫改变可能在covid -19相关精神病的发病机制中发挥作用。免疫异常主要归因于COVID-19感染的病理生理、使用的药物和压力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Behavioral Neuroscience Reports Medicine-Public Health, Environmental and Occupational Health

CiteScore

3.60

自引率

0.00%

发文量

期刊介绍： Under the leadership of Emil Coccaro, Current Behavioral Neuroscience Reports will provide an in-depth review of topics covering personality and impulse control disorders, psychosis, mood and anxiety disorders, genetics and neuroscience, geropsychiatry and cognitive disorders of late life, child and developmental psychiatry, addictions, and neuromodulation.We accomplish this aim by inviting international authorities to contribute review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. By providing clear, insightful balanced contributions, the journal intends to serve those involved in the field of behavioral neuroscience.