Shahab Haghayegh, Michael H Smolensky, Sepideh Khoshnevis, Ramon C Hermida, Richard J Castriotta, Kenneth R Diller
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引用次数: 6
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Abstract
Borbély proposed an interacting two-component model of sleep regulation comprising a homeostatic Process S and a circadian Process C. The model has provided understanding of the association between core body temperature (CBT) as a key element of Process C that is deterministic of sleep onset and offset. However, it additionally provides a new perspective of the importance of the thermoregulatory mechanisms of Process C in modulating the circadian rhythm of arterial blood pressure (ABP). Herein, we examine the circadian physiology of thermoregulation, including at the end of the activity span the profound redistribution of cardiac output from the systemic circulation to the arteriovenous anastomoses of the glabrous skin that markedly enhances convective transfer of heat from the body to the environment to cause (i) decrease of the CBT as a pathway to sleep onset and (ii) attenuation of the asleep ABP mean and augmentation of the ABP decline (dipping) from the wake-time mean, in combination the strongest predictors of the risk for blood vessel and organ pathology and morbid and mortal cardiovascular disease events. We additionally review the means by which blood perfusion to the glabrous skin can be manipulated on demand by selective thermal stimulation, that is, mild warming, on the skin of the cervical spinal cord to intensify Process C as a way to facilitate sleep induction and promote healthy asleep ABP. © 2021 American Physiological Society. Compr Physiol 11:1-14, 2021.
体温调节的昼夜节律调节睡眠/觉醒周期和24小时动脉血压模式。
borb提出了一个相互作用的双组分睡眠调节模型,包括一个稳态过程S和一个昼夜节律过程C。该模型提供了核心体温(CBT)作为过程C的关键因素之间的联系,这是睡眠开始和抵消的决定性因素。然而,它也为过程C在调节动脉血压昼夜节律(ABP)中的体温调节机制的重要性提供了新的视角。,我们检查昼夜生理温度调节,包括的活动跨越的再分配的心输出量体循环动静脉吻合的无毛皮肤明显提高对流热量的传递从身体对环境造成(i)减少CBT的途径开始睡觉,(ii)衰减睡着ABP的均值和ABP的增加下降(浸渍)起床的意思是,结合血管和器官病理以及病态和致命心血管疾病事件风险的最强预测因子。我们还回顾了通过选择性热刺激(即对颈脊髓皮肤进行温和加热)来根据需要控制无毛皮肤的血液灌注的方法,以加强C过程,作为促进睡眠诱导和促进健康睡眠的一种方式。©2021美国生理学会。物理学报(英文版),2011。
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