Obesity and diabetes are associated with disability in women with hand osteoarthritis. Results from the EpiReumaPt nationwide study.

IF 1 4区医学 Q4 RHEUMATOLOGY

Acta reumatologica portuguesa Pub Date : 2021-07-01

Margarida Cruz, Ana Maria Rodrigues, Sara Dias, Alexandre Sepriano, Helena Canhão, Nélia Gouveia, Sofia Ramiro, Jaime C Branco

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Abstract

Background: Hand osteoarthritis (HOA) is a highly prevalent rheumatic disease that predominates in females and causes pain and loss of functional capacity. Obesity and metabolic syndrome have been previously suggested to associate with the severity of HOA, but clarity on these associations is yet to be achieved.

Objective: Test the association between obesity and other components of the metabolic syndrome and disability in women with hand osteoarthritis (HOA).

Design: Individuals from EpiReumaPt epidemiological community-based study (2011-2013) are representative of the Portuguese population. Women with diagnosis of primary HOA were included.

Primary outcome: hand functional status, assessed by Cochin questionnaire.

Secondary outcomes: hand pain, assessed by visual analogue scale and tender hand joint count (THJ). Explanatory variables: obesity, diabetes mellitus, arterial hypertension and hypercholesterolemia. Possible associations between obesity and the other components of metabolic syndrome with Cochin score, hand pain and THJ were tested in a multivariable linear regression model. Potential confounders considered: age, education level and countrywide distribution.

Results: 473 women with primary HOA were included. Forty percent were overweight and 29% obese. Ninety-three (19.8%) participants had diabetes, 261 (55.8%) reported hypertension and 261 (55.9%) hypercholesterolemia. Mean Cochin score was 15.5±14.8, mean pain VAS was 4.7±2.6 and mean THJ 1.4±3. In the multivariable analysis, obesity (β 4.6 CI 0.7;8.5) and diabetes (β 4.0 CI 0.4;7.6) were found to significantly associate with HOA functional disability. In addition, diabetes, but not obesity, associated with hand pain. There was no association between obesity or diabetes with THJ.

Conclusion: In a Portuguese female population with primary HOA, obesity and diabetes mellitus independently associated with a worse hand functional status. These data add to evidence suggesting a role of metabolic factors in the severity of HOA.

本刊更多论文

肥胖和糖尿病与患有手骨关节炎的女性的残疾有关。EpiReumaPt全国研究的结果。

背景:手骨关节炎(HOA)是一种高度流行的风湿性疾病，主要见于女性，可导致疼痛和功能丧失。肥胖和代谢综合征先前被认为与HOA的严重程度有关，但尚未明确这些关联。目的:探讨女性手骨关节炎(HOA)患者代谢综合征的其他组成部分与肥胖的关系。设计:来自EpiReumaPt流行病学社区研究(2011-2013)的个体代表葡萄牙人口。诊断为原发性HOA的妇女也包括在内。主要观察指标:用Cochin问卷评估手功能状态。次要结果:手部疼痛，通过视觉模拟量表和柔软的手关节计数(THJ)评估。解释变量:肥胖、糖尿病、动脉高血压和高胆固醇血症。在多变量线性回归模型中检验肥胖与代谢综合征其他成分与Cochin评分、手部疼痛和THJ之间可能存在的关联。考虑到潜在的混杂因素:年龄、教育水平和全国分布。结果:纳入473例原发性HOA患者。40%的人超重，29%的人肥胖。93名(19.8%)参与者患有糖尿病，261名(55.8%)报告高血压，261名(55.9%)报告高胆固醇血症。平均Cochin评分为15.5±14.8，平均疼痛VAS评分为4.7±2.6，平均THJ评分为1.4±3。在多变量分析中，肥胖(β 4.6 CI 0.7;8.5)和糖尿病(β 4.0 CI 0.4;7.6)被发现与HOA功能残疾显著相关。此外，糖尿病与手痛有关，而不是肥胖。肥胖或糖尿病与THJ之间没有关联。结论:在葡萄牙原发性HOA女性人群中，肥胖和糖尿病与较差的手功能状态独立相关。这些数据进一步证明了代谢因素在HOA严重程度中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta reumatologica portuguesa 医学-风湿病学

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Reumatólogica Portuguesa is a scientific peer reviewed journal covering all aspects of rheumatic diseases and related to Rheumatology. The journal publishes original articles, reviews, clinical cases, images in rheumatology, letters to the editor and clinical teaching (e.g. guidelines and clinical protocols). Published since 1973, Acta Reumatológica Portuguesa is the official scientific publication of the Portuguese Society of Rheumatology, a non-profit organization that promotes the knowledge and investigation of rheumatic diseases and the development of Rheumatology.