The Clinical Significance of miR-21 in Guiding Chemotherapy for Patients with Osteosarcoma.

Pharmacogenomics and Personalized Medicine Pub Date : 2021-09-29 eCollection Date: 2021-01-01 DOI:10.2147/PGPM.S321637

Li-Zhi Li, Zhuang-Zhuang Wu, Zhi Lv

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引用次数: 1

Abstract

Objective: The present study aims to explore the correlation between osteosarcoma (OS) chemosensitivity and the expression levels of serum and tumor tissue micro-ribonucleic acid-21 (miR-21).

Methods: The relevant miR-21 expression levels in 30 patients with OS were detected, and the gender, age, tumor location, pathological type, Enneking stage, and miR-21 expression changes before and after chemotherapy were retrospectively analyzed.

Results: Serum and tumor tissue miR21 expression levels were significantly higher in patients with OS than in control subjects; the serum miR-21 expressions before and after chemotherapy were not related to patient age and gender. The effective chemotherapy group showed significant differences in miR-21 expression levels before and after chemotherapy.

Conclusion: Serum and tumor tissue miR-21 expression levels in patients with OS are closely related to the effects of chemotherapy, making miR-21 a potential biomarker and therapeutic target for the diagnosis and evaluation of chemotherapy effects on patients with OS.

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miR-21在骨肉瘤患者化疗指导中的临床意义

目的:本研究旨在探讨骨肉瘤(OS)化疗敏感性与血清及肿瘤组织微核糖核酸-21 (miR-21)表达水平的相关性。方法:检测30例OS患者的相关miR-21表达水平，并回顾性分析其性别、年龄、肿瘤部位、病理类型、Enneking分期及化疗前后miR-21表达变化。结果:OS患者血清及肿瘤组织miR21表达水平明显高于对照组;化疗前后血清miR-21表达与患者年龄、性别无关。有效化疗组化疗前后miR-21表达水平差异有统计学意义。结论:OS患者血清及肿瘤组织中miR-21的表达水平与化疗效果密切相关，miR-21可作为OS患者化疗效果诊断和评价的潜在生物标志物和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pharmacogenomics and Personalized Medicine

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