Complex interplay between p53 and chromosome stability.

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2021-06-28 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1938479

Akshay Narkar, Blake A Johnson, Rong Li

引用次数: 1

Abstract

TP53-dependent cell cycle arrest has been proposed to limit the proliferation of aneuploid cells. We investigated the cellular response to aneuploidy in cell lines and organoid cultures and found that TP53 (also known as p53) is not activated following aneuploidy induction in organoids. However, we confirmed that p53 is required for high mitotic fidelity. Our findings provide a revised view on how p53 safeguards against aneuploidy.

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p53与染色体稳定性之间的复杂相互作用。

依赖tp53的细胞周期阻滞已被提出用于限制非整倍体细胞的增殖。我们研究了细胞系和类器官培养中细胞对非整倍体的反应，发现TP53(也称为p53)在类器官非整倍体诱导后不被激活。然而，我们证实p53是高有丝分裂保真度所必需的。我们的研究结果为p53如何预防非整倍体提供了一个修订的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.