H Rothe, A Gaber, B Dittrich, M Nagel, M Tuffaha, B Hoschke
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引用次数: 1
Abstract
Background: Therapy of epitheloid angiomyolipomas (eAML) may be challenging, since unlike classical angiomyolipomas this rare subclass of benign mesenchymal angiomyolipomas may present with lymph node metastases, local recurrent disease, and/or systemic metastatic disease in up to 30% of cases.
Objectives: We report here for the first time in Germany a case of eAML after successful treatment of malignant melanoma.
Materials and methods: Clinical and histological findings as well as results of the genetic analysis of the angiomyolipoma are presented.
Results: A somatic, truncating mutation of the TSC2 gene was found in the angiomyolipoma.
Conclusion: The relationship to histologically similar tumor entities are presented and therapeutic options based on the genetic classification are discussed.
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