The Immune Response in Multiple Sclerosis.

IF 28.4 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2022-01-24 Epub Date: 2021-10-04 DOI:10.1146/annurev-pathol-052920-040318

Sofía Rodríguez Murúa, Mauricio F Farez, Francisco J Quintana

引用次数: 73

Abstract

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative disease that affects the central nervous system (CNS). MS is characterized by immune dysregulation, which results in the infiltration of the CNS by immune cells, triggering demyelination, axonal damage, and neurodegeneration. Although the exact causes of MS are not fully understood, genetic and environmental factors are thought to control MS onset and progression. In this article, we review the main immunological mechanisms involved in MS pathogenesis.

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多发性硬化症的免疫反应

多发性硬化症(MS)是一种慢性自身免疫、炎症和神经退行性疾病，影响中枢神经系统(CNS)。MS的特点是免疫失调，导致免疫细胞浸润中枢神经系统，引发脱髓鞘、轴突损伤和神经退行性变。虽然MS的确切病因尚不完全清楚，遗传和环境因素被认为控制MS的发病和进展。本文就MS发病的主要免疫机制作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.