The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2021-09-21 eCollection Date: 2021-01-01 DOI:10.1155/2021/1704762

Guoqing Yao, Wenjing Li, Wenzhao Liu, Jingbo Xing, Cheng Zhang

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引用次数: 1

Abstract

Objective: Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS).

Methods and results: Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls (P = 0.013). APA levels were slightly lower in the CAS group (P = 0.324). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly.

Conclusions: Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level.

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冠状动脉粥样硬化患者循环血管紧张素- iii水平及意义。

目的:血管紧张素- iii (angiotentin - iii, Ang-III)是氨基肽酶A (APA)代谢血管紧张素- ii (Ang-II)的下游产物。目前对Ang-III的研究主要集中在高血压和中枢肾素-血管紧张素系统(RAS)方面。然而，很少有研究关注Ang-III与冠状动脉粥样硬化(CAS)的关系。方法与结果:采用酶联免疫吸附试验(ELISA)测定44例正常人和84例经冠状动脉造影确诊的CAS患者血浆Ang-III和APA水平。CAS患者的循环Ang-III水平明显低于正常对照组(P = 0.013)。CAS组APA水平稍低(P = 0.324)。根据动脉粥样硬化的严重程度将CAS患者分为两组。与对照组相比，高评分组APA和Ang-III水平较低，且APA显著降低。结论:CAS患者循环Ang-III水平降低，可能与APA水平降低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.