{"title":"The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.","authors":"Guoqing Yao, Wenjing Li, Wenzhao Liu, Jingbo Xing, Cheng Zhang","doi":"10.1155/2021/1704762","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS).</p><p><strong>Methods and results: </strong>Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls (<i>P</i> = 0.013). APA levels were slightly lower in the CAS group (<i>P</i> = 0.324). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly.</p><p><strong>Conclusions: </strong>Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level.</p>","PeriodicalId":520698,"journal":{"name":"Journal of the renin-angiotensin-aldosterone system : JRAAS","volume":" ","pages":"1704762"},"PeriodicalIF":4.1000,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478585/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the renin-angiotensin-aldosterone system : JRAAS","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2021/1704762","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Objective: Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS).
Methods and results: Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls (P = 0.013). APA levels were slightly lower in the CAS group (P = 0.324). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly.
Conclusions: Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level.
目的:血管紧张素- iii (angiotentin - iii, Ang-III)是氨基肽酶A (APA)代谢血管紧张素- ii (Ang-II)的下游产物。目前对Ang-III的研究主要集中在高血压和中枢肾素-血管紧张素系统(RAS)方面。然而，很少有研究关注Ang-III与冠状动脉粥样硬化(CAS)的关系。方法与结果:采用酶联免疫吸附试验(ELISA)测定44例正常人和84例经冠状动脉造影确诊的CAS患者血浆Ang-III和APA水平。CAS患者的循环Ang-III水平明显低于正常对照组(P = 0.013)。CAS组APA水平稍低(P = 0.324)。根据动脉粥样硬化的严重程度将CAS患者分为两组。与对照组相比，高评分组APA和Ang-III水平较低，且APA显著降低。结论:CAS患者循环Ang-III水平降低，可能与APA水平降低有关。
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