Inflammatory Mechanism and Clinical Implication of Asthma in COVID-19.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-09-24 eCollection Date: 2021-01-01 DOI:10.1177/11795484211042711

Vasa Adi Wisnu Wardana, Alfian Nur Rosyid

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引用次数: 5

Abstract

Asthma is a chronic inflammatory disease of the respiratory tract that has become a public health problem in various countries. Referring to the Global Initiative for Asthma, the prevalence of asthma continues to increase especially in children. Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that has declared a pandemic by the world health organization on March 2020. For many years, it has been known that people with asthma have a worse impact on respiratory viral infections. Asthma has been listed by the centers for disease control and prevention as one of the risk factors for COVID-19, although several studies have different results. SARS-CoV-2 utilizes angiotensin-converting enzyme 2 (ACE2) as its cellular receptor, and it has been known that the expression of the ACE2 receptor is reduced in asthma patients. This reduced expression could also be accounted from the therapy of asthma. This paper aims to discuss the pathophysiology of asthma and COVID-19 and the susceptibility of asthma patients in contracting COVID-19.

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新冠肺炎患者哮喘的炎症机制及临床意义。

哮喘是一种慢性呼吸道炎症性疾病，已成为各国的公共卫生问题。根据全球哮喘倡议，哮喘的患病率继续增加，尤其是儿童。2019冠状病毒病(COVID-19)是由严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)引起的传染病，于2020年3月被世界卫生组织宣布为大流行。多年来，人们已经知道哮喘患者对呼吸道病毒感染的影响更大。尽管几项研究的结果不同，但哮喘已被疾病控制和预防中心列为COVID-19的危险因素之一。SARS-CoV-2利用血管紧张素转换酶2 (ACE2)作为其细胞受体，已知哮喘患者中ACE2受体的表达降低。这种表达的减少也可以从哮喘的治疗中得到解释。本文旨在探讨哮喘与新冠肺炎的病理生理及哮喘患者感染新冠肺炎的易感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.