The HIV-1 capsid and reverse transcription.

IF 2.7 3区医学 Q3 VIROLOGY

Retrovirology Pub Date : 2021-09-25 DOI:10.1186/s12977-021-00566-0

Christopher Aiken, Itay Rousso

引用次数: 18

Abstract

The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramatically enhances reverse transcription in vitro by stabilizing the viral capsid. Reverse transcription results in marked changes in the biophysical properties of the capsid, ultimately resulting in its breakage and disassembly. Here we review the research leading to these advances and describe hypotheses for capsid-dependent HIV-1 reverse transcription and a model for reverse transcription-primed HIV-1 uncoating.

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HIV-1衣壳和逆转录。

病毒衣壳在HIV-1逆转录中起关键作用。最近的研究表明，小分子IP6通过稳定病毒衣壳而显著增强体外逆转录。逆转录导致衣壳生物物理性质发生显著变化，最终导致衣壳断裂和解体。在这里，我们回顾了导致这些进展的研究，并描述了衣壳依赖性HIV-1反转录的假设和逆转录引发的HIV-1剥膜模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retrovirology 医学-病毒学

CiteScore

5.80

自引率

3.00%

发文量

审稿时长

>0 weeks

期刊介绍： Retrovirology is an open access, online journal that publishes stringently peer-reviewed, high-impact articles on host-pathogen interactions, fundamental mechanisms of replication, immune defenses, animal models, and clinical science relating to retroviruses. Retroviruses are pleiotropically found in animals. Well-described examples include avian, murine and primate retroviruses. Two human retroviruses are especially important pathogens. These are the human immunodeficiency virus, HIV, and the human T-cell leukemia virus, HTLV. HIV causes AIDS while HTLV-1 is the etiological agent for adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. Retrovirology aims to cover comprehensively all aspects of human and animal retrovirus research.