Medication prescriptions before, during and after pregnancy in Italy: a population-based study.

IF 1.1 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annali dell'Istituto superiore di sanita Pub Date : 2021-07-01 DOI:10.4415/ANN_21_03_09

Filomena Fortinguerra, Valeria Belleudi, Francesca Romana Poggi, Renata Bortolus, Aurora Puccini, Valentina Solfrini, Paolo Stella, Francesco Trotta

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引用次数: 2

Abstract

Background: Monitoring medicine prescriptions in pregnancy is an aspect of extreme interest in term of public health.

Methods: A retrospective prevalence study using administrative healthcare databases was performed in order to evaluate medication prescriptions in Italy. A cohort of 274,938 pregnant women (15-49 years) residing in three Italian regions (Emilia-Romagna, Lazio, Puglia), who delivered in 2014-2017, were enrolled. The prevalence of medication use was estimated as the proportion of pregnant women with any medication prescription in each of the following five trimesters: 1 before pregnancy (pre-T), 3 during pregnancy (1st TP, 2nd TP, 3rd TP) and 1 after pregnancy (post-T).

Results: About 80% of enrolled pregnant women received at least one prescription during pregnancy, 36.5% before pregnancy and 50.7% in the post-partum. The most prescribed medicine was folic acid (42%), mostly used in 1st TP (35%). Progesterone use was concentrated in 1st TP (19%) and increased as the number of previous abortions. Pregnancy use of antidiabetics, antihypertensives, and thyroid preparations were 24.1‰, 21.5‰, 101.8‰, respectively.

Conclusions: At the national level, this study confirmed the prescriptive trend observed in other European studies, but a regional variability for all medication groups was found. Further studies are needed in order to identify determinants of medication prescriptions during pregnancy in Italy.

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意大利孕前、孕期和产后的药物处方:一项基于人群的研究。

背景:监测妊娠期药物处方是公共卫生领域极为关注的一个方面。方法:利用行政卫生保健数据库进行回顾性患病率研究，以评估意大利的药物处方。研究纳入了居住在意大利三个地区(艾米利亚-罗马涅、拉齐奥、普利亚)的274,938名孕妇(15-49岁)，这些孕妇于2014-2017年分娩。药物使用的流行率估计为在以下五个妊娠期中每个妊娠期有任何药物处方的孕妇的比例:妊娠前1例(t前)，妊娠期间3例(第1、2、3 TP)，妊娠后1例(t后)。结果:约80%的孕妇在怀孕期间、孕前和产后至少服用过一次处方，其中36.5%的孕妇服用过处方，50.7%的孕妇服用过处方。处方药物最多的是叶酸(42%)，主要用于第一次TP(35%)。黄体酮的使用主要集中在第一期(19%)，并随着既往流产次数的增加而增加。妊娠使用降糖药、降压药、甲状腺制剂的比例分别为24.1‰、21.5‰、101.8‰。结论:在国家层面，本研究证实了在其他欧洲研究中观察到的处方趋势，但发现所有药物组存在区域差异。需要进行进一步的研究，以确定意大利怀孕期间药物处方的决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annali dell'Istituto superiore di sanita PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

>12 weeks

期刊介绍： Annali dell’Istituto Superiore di Sanità is a peer reviewed quarterly science journal which publishes research articles in biomedicine, translational research and in many other disciplines of the health sciences. The journal includes the following material: original articles, reviews, commentaries, editorials, brief and technical notes, book reviews. The publication of Monographic Sections has been discontinued. In case you wish to present a small number of coordinated contributions on specific themes concerning priorities in public health, please contact the Editorial office. The journal is in English.