Peripheral vestibular system: Age-related vestibular loss and associated deficits

IF 1.4 Q2 OTORHINOLARYNGOLOGY
Jennifer Coto , Carmen L. Alvarez , Ivette Cejas , Brett M. Colbert , Bonnie E. Levin , Joshua Huppert , Tatjana Rundek , Carey Balaban , Susan H. Blanton , David J. Lee , David Loewenstein , Michael Hoffer , Xue Zhong Liu
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引用次数: 8

Abstract

Given the interdependence of multiple factors in age-related vestibular loss (e.g., balance, vision, cognition), it is important to examine the individual contributions of these factors with ARVL. While the relationship between the vestibular and visual systems has been well studied (Bronstein et al., 2015), little is known about the association of the peripheral vestibular system with neurodegenerative disorders (Cronin et al., 2017). Further, emerging research developments implicate the vestibular system as an opportunity for examining brain function beyond balance, and into other areas, such as cognition and psychological functioning. Additionally, the bidirectional impact of psychological functioning is understudied in ARVL. Recognition of ARVL as part of a multifaceted aging process will help guide the development of integrated interventions for patients who remain at risk for decline. In this review, we will discuss a wide variety of characteristics of the peripheral vestibular system and ARVL, how it relates to neurodegenerative diseases, and correlations between ARVL and balance, vision, cognitive, and psychological dysfunction. We also discuss clinical implications as well as future directions for research, with an emphasis on improving care for patients with ARVL.

Abstract Image

外周前庭系统:与年龄相关的前庭功能丧失和相关缺陷
考虑到与年龄相关的前庭功能丧失(如平衡、视力、认知)的多种因素相互依赖,检查这些因素对ARVL的个体影响是很重要的。虽然前庭和视觉系统之间的关系已经得到了很好的研究(Bronstein et al., 2015),但对周围前庭系统与神经退行性疾病的关系知之甚少(Cronin et al., 2017)。此外,新兴的研究发展暗示前庭系统作为一个机会来检查大脑功能超越平衡,并进入其他领域,如认知和心理功能。此外,心理功能在ARVL中的双向影响尚未得到充分研究。认识到ARVL是多方面衰老过程的一部分,将有助于指导为仍有衰退风险的患者制定综合干预措施。在这篇综述中,我们将讨论周围前庭系统和ARVL的各种特征,它与神经退行性疾病的关系,以及ARVL与平衡、视觉、认知和心理功能障碍的关系。我们还讨论了临床意义以及未来的研究方向,重点是改善对ARVL患者的护理。
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来源期刊
Journal of Otology
Journal of Otology Medicine-Otorhinolaryngology
CiteScore
2.70
自引率
0.00%
发文量
461
审稿时长
18 days
期刊介绍: Journal of Otology is an open access, peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear. This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with disorders of the auditory and vestibular systems. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines. Journal of Otology welcomes contributions from scholars in all countries and regions across the world.
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