Gelatin-based instant gel-forming volatile spray for wound-dressing application.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Progress in Biomaterials Pub Date : 2021-09-01 Epub Date: 2021-09-20 DOI:10.1007/s40204-021-00166-3
Mohammed Shahidul Islam, Jahid M M Islam, M Fizur Rahman, Mohammed Mizanur Rahman, Mubarak A Khan
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引用次数: 5

Abstract

This study was a successful endeavor to develop and investigate the suitability of a bioadhesive wound-healing gel based on gelatin for first-aid purposes. Polyethylene glycol (PEG) was used to prepare a denser phase of gelatin chains, and diethyl ether (DEE) was used to introduce high volatility to the solution. The prepared solution was stable in the storage container but rapidly formed (within 3 s) a protective and bioadhesive gel around the wound surface by being sprayed over the wound. Besides, it also suppressed pain and showed moderate antimicrobial activity against S. aureus. It was also found highly biocompatible and non-toxic. All the results revealed that the prepared solution could be an effective candidate for treating minor injuries or burn, especially for a first-aid purpose.

Abstract Image

明胶为基础的即时凝胶形成挥发性喷雾伤口敷料应用。
本研究成功地开发和研究了一种基于明胶的生物黏附伤口愈合凝胶用于急救目的的适用性。聚乙二醇(PEG)用于制备凝胶链的致密相,乙醚(DEE)用于引入高挥发性的溶液。制备的溶液在储存容器中稳定,但通过喷洒在创面上,在创面周围迅速形成保护性的生物粘附凝胶(3 s内)。此外,对金黄色葡萄球菌具有抑制疼痛和中等抑菌活性的作用。它还被发现具有高度的生物相容性和无毒。所有结果表明,制备的溶液可以有效地治疗轻微损伤或烧伤,特别是急救目的。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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