Coronary Inflammation Assessed by Perivascular Fat Attenuation Index in Patients with Psoriasis: A Propensity Score-Matched Study.

Dermatology (Basel, Switzerland) Pub Date : 2022-01-01 Epub Date: 2021-09-15 DOI:10.1159/000518771

Wenrui Bao, Min Yang, Zhihan Xu, Fuhua Yan, Qi Yang, Xia Li, Wenjie Yang

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引用次数: 3

Abstract

Objectives: This study aimed to evaluate coronary inflammation by measuring the perivascular fat attenuation index (FAI) and quantify the atherosclerosis burden in patients with psoriasis and control individuals without psoriasis based on coronary computed tomography angiography (CCTA) images.

Methods: A total of 98 consecutive patients with psoriasis (76 male [77.6%], aged 56.5 years, range 45.5-65.0) were recruited, and 196 patients (157 male [80.1%]; aged 54.6 ± 14.1 years) without established cardiovascular disease (CVD) who underwent CCTA within the same period were enrolled in the control group. Coronary plaque burden was quantified using the computed tomography-adapted Leaman score (CT-LeSc), and the FAI surrounding the proximal of three main epicardial vessels was measured to represent coronary inflammation.

Results: Patients with psoriasis and the control subjects were well matched in CVD risk factors (all p > 0.05). Psoriasis patients had a greater overall CT-LeSc (5.86 vs. 4.69, p = 0.030) and lower perivascular FAI (-80.19 ± 7.48 vs. -78.14 ± 7.81 HU, p < 0.001). A similar result was found upon comparing psoriasis patients without biological or statin therapy with non-psoriasis individuals without statin treatments. Furthermore, the psoriasis group had a higher prevalence of non-calcified plaques (30.3% in the psoriasis group vs. 20.1% in the control subjects, p = 0.001). No difference in perivascular FAI on either calcified and mixed plaques or non-calcified plaques between the two groups was found.

Conclusion: Patients with psoriasis have a higher atherosclerotic burden as quantified by CT-LeSc and less coronary inflammation as detected by perivascular FAI around the most proximal of the three major epicardial vessels. The usefulness of perivascular FAI for evaluating coronary inflammation in patients with chronic low-grade inflammatory disease such as psoriasis should be verified.

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银屑病患者血管周围脂肪衰减指数评估冠状动脉炎症:一项倾向评分匹配研究。

目的:本研究旨在基于冠状动脉ct血管造影(CCTA)图像，通过测量血管周围脂肪衰减指数(FAI)来评估银屑病患者和对照组的冠状动脉炎症，并量化银屑病患者和非银屑病对照组的动脉粥样硬化负担。方法:共招募98例牛皮癣患者(男性76例[77.6%]，年龄56.5岁，范围45.5 ~ 65.0)，196例患者(男性157例[80.1%];对照组为年龄54.6±14.1岁，无明确心血管疾病(CVD)，同期行CCTA治疗。冠状动脉斑块负荷采用CT-LeSc量化，并测量三条主要心外膜血管近端周围的FAI，以代表冠状动脉炎症。结果:银屑病患者与对照组CVD危险因素匹配良好(p > 0.05)。银屑病患者总体CT-LeSc较高(5.86比4.69,p = 0.030)，血管周围FAI较低(-80.19±7.48比-78.14±7.81 HU, p < 0.001)。在比较没有生物或他汀类药物治疗的牛皮癣患者与没有他汀类药物治疗的非牛皮癣患者时，发现了类似的结果。此外，银屑病组非钙化斑块的患病率更高(银屑病组为30.3%，对照组为20.1%，p = 0.001)。钙化斑块、混合斑块和非钙化斑块的血管周围FAI在两组之间均无差异。结论:CT-LeSc量化银屑病患者有较高的动脉粥样硬化负担，而三根主要心外膜血管最近端的血管周围FAI检测到的冠状动脉炎症较少。对于慢性低级别炎症性疾病(如牛皮癣)患者，血管周围FAI评估冠状动脉炎症的有效性有待证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dermatology (Basel, Switzerland)

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