Chitosan Displays a Potent Caloric Restriction Mimetic Effect in Senescent Rats.

IF 2.2 4区 医学 Q3 GERIATRICS & GERONTOLOGY
Raushan Kumar, Munish Kumar, Syed Ibrahim Rizvi
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引用次数: 3

Abstract

Chitosan is a polysaccharide made up of β1,4-linked d-glucosamine (GlcN) and N-acetyl-GlcN. In this study, we evaluated the possible caloric restriction mimetic (CRM) effect of dietary chitosan on systemic redox status, inflammatory biomarkers, and lipid profile in plasma and erythrocyte samples of d-galactose-induced mimetically aged rats. We found a significant increase (p < 0.05) in the reactive oxygen species, protein carbonyl, fasting glucose, body weight, cholesterol, triglyceride, inflammatory markers-interleukin-6 and tumor necrosis factor-alpha in an accelerated senescent rat model. There was also a significant decrease (p < 0.05) in glutathione, advanced glycation end product in senescent rats. Chitosan treatment increased ferric-reducing antioxidant potential, glutathione, plasma membrane-reduced system in accelerated senescent model of rats. Our finding suggests that chitosan has properties similar to a CRM and can effectively maintain the redox homeostasis during the aging process in rat erythrocytes.

壳聚糖在衰老大鼠中显示出强有力的热量限制模拟效应。
壳聚糖是一种由β1,4-连接d-葡萄糖胺(GlcN)和n -乙酰-GlcN组成的多糖。在这项研究中,我们评估了饮食中壳聚糖对d-半乳糖诱导的模拟衰老大鼠血浆和红细胞样本中系统氧化还原状态、炎症生物标志物和脂质谱的可能的热量限制模拟(CRM)效应。我们发现(p。p。
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来源期刊
Rejuvenation research
Rejuvenation research 医学-老年医学
CiteScore
4.50
自引率
0.00%
发文量
41
审稿时长
3 months
期刊介绍: Rejuvenation Research publishes cutting-edge, peer-reviewed research on rejuvenation therapies in the laboratory and the clinic. The Journal focuses on key explorations and advances that may ultimately contribute to slowing or reversing the aging process, and covers topics such as cardiovascular aging, DNA damage and repair, cloning, and cell immortalization and senescence. Rejuvenation Research coverage includes: Cell immortalization and senescence Pluripotent stem cells DNA damage/repair Gene targeting, gene therapy, and genomics Growth factors and nutrient supply/sensing Immunosenescence Comparative biology of aging Tissue engineering Late-life pathologies (cardiovascular, neurodegenerative and others) Public policy and social context.
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