Hyaluronic acid-based drug nanocarriers as a novel drug delivery system for cancer chemotherapy: A systematic review.

Nader Salari, Kamran Mansouri, Elahe Valipour, Farzaneh Abam, Mehdi Jaymand, Shna Rasoulpoor, Sadat Dokaneheifard, Masoud Mohammadi
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引用次数: 16

Abstract

Chemotherapy is the most common treatment strategy for cancer patients. Nevertheless, limited drug delivery to cancer cells, intolerable toxicity, and multiple drug resistance are constant challenges of chemotherapy. Novel targeted drug delivery strategies by using nanoparticles have attracted much attention due to reducing side effects and increasing drug efficacy. Therefore, the most important outcome of this study is to answer the question of whether active targeted HA-based drug nanocarriers have a significant effect on improving drug delivery to cancer cells.This study aimed to systematically review studies on the use of hyaluronic acid (HA)-based nanocarriers for chemotherapy drugs. The two databases MagIran and SID from Persian databases as well as international databases PubMed, WoS, Scopus, Science Direct, Embase, as well as Google Scholar were searched for human studies and cell lines and/or xenograft mice published without time limit until 2020. Keywords used to search included Nanoparticle, chemotherapy, HA, Hyaluronic acid, traditional medicine, natural medicine, chemotherapeutic drugs, natural compound, cancer treatment, and cancer. The quality of the studies was assessed by the STROBE checklist. Finally, studies consistent with inclusion criteria and with medium- to high-quality were included in the systematic review.According to the findings of studies, active targeted HA-based drug nanocarriers showed a significant effect on improving drug delivery to cancer cells. Also, the use of lipid nanoparticles with a suitable coating of HA have been introduced as biocompatible drug carriers with high potential for targeted drug delivery to the target tissue without affecting other tissues and reducing side effects. Enhanced drug delivery, increased therapeutic efficacy, increased cytotoxicity and significant inhibition of tumor growth, as well as high potential for targeted chemotherapy are also reported to be benefits of using HA-based nanocarriers for tumors with increased expression of CD44 receptor.

基于透明质酸的药物纳米载体作为一种新的癌症化疗药物传递系统:系统综述。
化疗是癌症患者最常用的治疗策略。然而,有限的药物输送到癌细胞,难以忍受的毒性和多重耐药是化疗的持续挑战。纳米颗粒靶向给药策略因其减少副作用和提高药物疗效而备受关注。因此,本研究最重要的结果是回答了基于ha的活性靶向药物纳米载体是否对改善药物递送到癌细胞有显著作用的问题。本研究旨在系统综述透明质酸纳米载体在化疗药物中的应用研究。检索来自波斯数据库的MagIran和SID两个数据库,以及国际数据库PubMed、WoS、Scopus、Science Direct、Embase和Google Scholar,检索人类研究和发表的细胞系和/或异种移植小鼠,没有时间限制,直到2020年。搜索的关键词包括纳米粒子、化疗、透明质酸、传统药物、天然药物、化疗药物、天然化合物、癌症治疗、癌症。通过STROBE检查表评估研究的质量。最后,符合纳入标准和中等至高质量的研究被纳入系统评价。研究发现,活性靶向ha基药物纳米载体对改善药物向癌细胞的传递有显著作用。此外,脂质纳米颗粒与合适的透明质酸涂层的使用已经被引入作为生物相容性药物载体,具有高潜力的靶向药物递送到目标组织,而不影响其他组织并减少副作用。据报道,在CD44受体表达增加的肿瘤中,使用ha纳米载体的好处还包括增强药物传递、提高治疗效果、增加细胞毒性和显著抑制肿瘤生长,以及靶向化疗的高潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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