Changes of Gastric Juice Microenvironment in Patients with Fundic Gland Polyp and Hyperplastic Polyp.

Pathobiology : journal of immunopathology, molecular and cellular biology Pub Date : 2021-01-01 Epub Date: 2021-09-09 DOI:10.1159/000516855

He Gao, Lili Chang, Limin Wang, Xiaona Zhou, Ning Wang

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引用次数: 1

Abstract

Introduction: The aim of this study was to study the relationship between the formation of gastric fundic gland polyp and gastric hyperplastic polyp (HP) and the changes of gastric juice microenvironment.

Methods: The proton-pump inhibitor (PPI) applications to patients were recorded. Gastric juices and biopsy polyps were collected for pathological examination, H. pylori tests, biomarkers, and MUC1, MUC2, MUC5AC expression measurement.

Results: Among 34,892 patients, the detection rate of gastric fundic gland polyps was significantly higher than that of gastric HPs (p < 0.01). The incidence rate of gastric fundic gland polyp and gastric HP in PPI users (n = 3,886) was higher than that of non-PPI users (p < 0.01). The occurrence of polyp was positively related to the duration of PPI application and the H. pylori-positive rate. The bile reflux rate between fundic gland polys group (17.61%) and HPs (28.67%) was significantly different (p < 0.01). The levels of gastric juice Gastrin-17, epidermal growth factor (EGF) and MUC2 from patients with gastric fundic gland polyps and gastric HPs were higher than those in the control group (p < 0.01). However, patients with gastric fundic gland polyps and HPs had significantly lower gastric juice PGE2 and MUC5AC (p < 0.01).

Conclusion: PPI application, H. pylori infection, and bile reflux are the potential risk factors for formation of fundic gland polyps and HPs. The potential mechanism of polyps' formation can be related to the levels of Gastrin-17, EGF, MUC2, PGE2, and MUC5AC in gastric juice.

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基底腺息肉和增生性息肉患者胃液微环境的变化。

前言:本研究旨在研究胃底腺息肉和胃增生性息肉(HP)的形成与胃液微环境的变化之间的关系。方法:记录质子泵抑制剂(PPI)在患者中的应用情况。收集胃液和活检息肉进行病理检查、幽门螺杆菌检查、生物标志物检测和MUC1、MUC2、MUC5AC表达测定。结果:34,892例患者中，胃底腺息肉的检出率显著高于胃hp (p < 0.01)。PPI使用者胃底腺息肉和胃HP的发生率(n = 3886)高于非PPI使用者(p < 0.01)。息肉的发生与PPI使用时间和幽门螺杆菌阳性率呈正相关。胰底腺息肉组胆汁反流率(17.61%)与胰底腺息肉组(28.67%)差异有统计学意义(p < 0.01)。胃底腺息肉和胃HPs患者的胃液胃泌素-17、表皮生长因子(EGF)和MUC2水平均高于对照组(p < 0.01)。而胃底腺息肉和hp患者的胃液PGE2和MUC5AC明显降低(p < 0.01)。结论:PPI应用、幽门螺杆菌感染、胆汁反流是基底腺息肉和hp形成的潜在危险因素。息肉形成的潜在机制可能与胃液中胃泌素-17、EGF、MUC2、PGE2和MUC5AC的水平有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pathobiology : journal of immunopathology, molecular and cellular biology

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