Evidence-Based Recommendations for Nurse Monitoring and Management of Immunotherapy-Induced Cytokine Release Syndrome: A Systematic Review from the Children's Oncology Group.

IF 1.9 3区 医学 Q2 NURSING
Journal of Pediatric Oncology Nursing Pub Date : 2021-11-01 Epub Date: 2021-08-30 DOI:10.1177/10434542211040203
Emily K Browne, Emily Daut, Monica Hente, Kelly Turner, Katherine Waters, Elizabeth A Duffy
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引用次数: 3

Abstract

Children with B-precursor acute lymphoblastic leukemia and B-cell lymphoma, particularly those with relapsed or refractory disease, are increasingly enrolled on phase II and phase III clinical trials studying immunotherapies. These therapeutic agents may be associated with a high risk of cytokine release syndrome (CRS), and nurses lack standardized guidelines for monitoring and managing patients with CRS. Six studies and one clinical practice guideline were included in this systematic review that examined the evidence of CRS following administration of chimeric antigen receptor T-cell therapy or the bi-specific T-cell engager antibody, blinatumomab. Six nursing practice recommendations (five strong, one weak) were developed based on low or very low-quality evidence: three reflect preinfusion monitoring, one focuses on monitoring during and postinfusion, and three pertain to the nurse's role in CRS management.

Abstract Image

免疫治疗诱导的细胞因子释放综合征的护士监测和管理的循证建议:来自儿童肿瘤组的系统综述。
患有b前体急性淋巴细胞白血病和b细胞淋巴瘤的儿童,特别是那些复发或难治性疾病的儿童,越来越多地参加研究免疫疗法的II期和III期临床试验。这些治疗药物可能与细胞因子释放综合征(CRS)的高风险相关,护士缺乏监测和管理CRS患者的标准化指南。本系统综述包括六项研究和一项临床实践指南,检查了嵌合抗原受体t细胞治疗或双特异性t细胞结合抗体blinatumomab后CRS的证据。根据低质量或极低质量的证据制定了6项护理实践建议(5项强,1项弱):3项反映输液前监测,1项侧重于输液期间和输液后监测,3项涉及护士在CRS管理中的作用。
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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: SPECIAL PATIENTS NEED SPECIAL NURSES Caring for children with cancer is one of the most technically and emotionally difficult areas in nursing. Not only are you dealing with children and adolescents who hurt, you must reassure and educate families, balance a multitude of other health care professionals, and keep up with ever-changing nursing practice and care. To help special nurses stay aware of the newest effective nursing practices, innovative therapeutic approaches, significant information trends, and most practical research in hematology and pediatric oncology nursing, you need the Journal of Pediatric Oncology Nursing. The journal offers pediatric hematology, oncology, and immunology nurses in clinical practice and research, pediatric social workers, epidemiologists, clinical psychologists, child life specialists and nursing educators the latest peer-reviewed original research and definitive reviews on the whole spectrum of nursing care of childhood cancers, including leukemias, solid tumors and lymphomas, and hematologic disorders. JOPON covers the entire disease process--diagnosis, treatment, recovery, and survival, as well as end-of-life care. Six times a year, the Journal of Pediatric Oncology Nursing introduces new and useful nursing care practice and research from around the world that saves you time and effort. Just some of the spirited topics covered include: Cancer survivorship including later-life effects of childhood cancer, including fertility, cardiac insufficiency, and pulmonary fibrosis Combination therapies Hematologic and immunologic topics Holistic, family-centered supportive care Improvement of quality of life for children and adolescents with cancer Management of side effects from surgery, chemotherapy, and radiation Management of specific symptoms/diseases/co-infections Medication tolerance differences in children and adolescents Pain control Palliative and end of life care issues Pharmacologic agents for pediatrics/clinical trial results Psychological support for the patient, siblings, and families The dynamic articles cover a wide range of specific nursing concerns, including: Advanced practice issues Clinical issues Clinical proficiency Conducting qualitative and quantitative research Developing a core curriculum for pediatric hematology/oncology nursing Encouraging active patient participation Ethical issues Evaluating outcomes Professional development Stress management and handling your own emotions Other important features include Guest Editorials from experts in the discipline, Point/Counterpoint debates, Roadmaps (personal insights into the nursing experience), and Proceedings and Abstracts from the annual Association for Pediatric Hematology/Oncology Nurses (APHON) conference. Your special patients need special nurses--stay special by subscribing to the Journal of Pediatric Oncology Nursing today! This journal is a member of the Committee on Publication Ethics (COPE).
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