Endocrine-Disrupting Chemicals and Disorders of Penile Development in Humans.

IF 2.4 4区医学 Q2 DEVELOPMENTAL BIOLOGY

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-08-26 DOI:10.1159/000517157

Laura Gaspari, Benoit Tessier, Françoise Paris, Anne Bergougnoux, Samir Hamamah, Charles Sultan, Nicolas Kalfa

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引用次数: 5

Abstract

This paper reviews the current knowledge on the environmental effects on penile development in humans. The specific focus is on endocrine-disrupting chemicals (EDCs), a heterogeneous group of natural or manmade substances that interfere with endocrine function, and whether they can induce hypospadias and micropenis in male neonates. Epidemiological data and animal observations first raised suspicions about environmental effects, leading to the testis dysgenesis syndrome (TDS) hypothesis. More recent research has provided stronger indications that TDS may indeed be the result of the direct or indirect effects of EDCs. Drawing on epidemiological and toxicological studies, we also report on the effects of maternal diet and substances like pesticides, phthalates, bisphenol A, and polychlorinated biphenyls. Proximity to contamination hazards and occupational exposure are also suspected to contribute to the occurrence of hypospadias and micropenis. Lastly, the cumulative effects of EDCs and the possibility of transgenerational effects, with the penile development of subsequent generations being affected, raise concerns for long-term public health.

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内分泌干扰物与人类阴茎发育障碍。

本文综述了环境对人类阴茎发育影响的最新研究进展。具体的重点是内分泌干扰化学物质(EDCs)，这是一组干扰内分泌功能的天然或人造物质，以及它们是否会导致男性新生儿尿道下裂和小阴茎。流行病学数据和动物观察首先提出了对环境影响的怀疑，导致睾丸发育不良综合征(TDS)假说。最近的研究提供了更有力的迹象，表明TDS确实可能是EDCs直接或间接影响的结果。根据流行病学和毒理学研究，我们还报告了母亲饮食和杀虫剂、邻苯二甲酸盐、双酚A和多氯联苯等物质的影响。接近污染危害和职业暴露也被怀疑有助于尿道下裂和小阴茎的发生。最后，EDCs的累积效应和跨代效应的可能性，随着后代的阴茎发育受到影响，引起了对长期公共卫生的关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sexual Development 生物-发育生物学

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Recent discoveries in experimental and clinical research have led to impressive advances in our knowledge of the genetic and environmental mechanisms governing sex determination and differentiation, their evolution as well as the mutations or endocrine and metabolic abnormalities that interfere with normal gonadal development. ‘Sexual Development’ provides a unique forum for this rapidly expanding field. Its broad scope covers all aspects of genetics, molecular biology, embryology, endocrinology, evolution and pathology of sex determination and differentiation in humans and animals. It publishes high-quality original research manuscripts, review articles, short reports, case reports and commentaries. An internationally renowned and multidisciplinary editorial team of three chief editors, ten prominent scientists serving as section editors, and a distinguished panel of editorial board members ensures fast and author-friendly editorial processing and peer reviewing.