Prevalence and incidence of primary hyperparathyroidism in Bahrain: A retrospective study from one medical center.

IF 0.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Neuro endocrinology letters Pub Date : 2021-08-28

Jehan Abdulla, Yasmeen M Suwaifi

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引用次数: 0

Abstract

Objectives: Primary hyperparathyroidism (PHPT) is considered the third endocrine disorder worldwide. However, the incidence of PHPT is variable in different populations. Since there are no studies on PHPT performed in Bahrain or the surrounding Arab Middle Eastern countries, this study aimed to determine the prevalence and incidence of PHPT and its variants in Bahrain.

Methods: A retrospective study was conducted over a 3-year period (2018-2020) at the Bahrain Defense Force Military Hospital. Patients' data with normal kidney function, age 14 years and older, and had related laboratory results (calcium, PTH, phosphorus, and vitamin D) were retrieved and analyzed for prevalence and incidence of hypercalcemia and PHPT according to age and sex.

Results: Out of 9650 patients, 417 patients had corrected hypercalcemia. Of these, 240, 125, and 88 patients per 100,000 had classic, non-classic, or early/normocalcemic PHPT, respectively. These numbers resulted in a prevalence of PHPT of 274 per 100,000 in Bahrain. The age-adjusted incidence of all types of PHPT was 179 per 100,000/year. Overall, PHPT incidence, whether classic or not, significantly increased in the 50 years age group and above (OR 1.023 with 95% CI 1.013-1.033). Furthermore, hypercalcemia and non-classic PHPT were predominant in females than males. Lastly, vitamin D level was significantly less in classic PHPT than the non-classic variant.

Conclusion: The high prevalence and incidence of PHPT should alarm physicians and clinical practices in Bahrain and the Middle East region to investigate routinely for classic and non-classic PHPT to control and manage the complications that arise from PHPT. However, more epidemiological studies in the Middle East region are warranted to investigate the reasons behind the high incidence of PHPT.

本刊更多论文

巴林原发性甲状旁腺功能亢进症的患病率和发病率：来自一家医疗中心的回顾性研究。

目标：原发性甲状旁腺功能亢进症（PHPT原发性甲状旁腺功能亢进症（PHPT）被认为是全球第三大内分泌疾病。然而，PHPT 在不同人群中的发病率各不相同。由于巴林或周边阿拉伯中东国家尚未开展有关 PHPT 的研究，本研究旨在确定 PHPT 及其变异型在巴林的患病率和发病率：巴林国防军军事医院开展了一项为期 3 年（2018-2020 年）的回顾性研究。检索肾功能正常、年龄在 14 岁及以上、有相关实验室结果（钙、PTH、磷和维生素 D）的患者数据，并根据年龄和性别分析高钙血症和 PHPT 的患病率和发病率：在9650名患者中，有417名患者的高钙血症得到了纠正。其中，每 10 万名患者中分别有 240 人、125 人和 88 人患有典型、非典型或早期/正常钙血症型 PHPT。根据这些数据，巴林的 PHPT 患病率为每 10 万人 274 例。所有类型的 PHPT 经年龄调整后的发病率为 179/100,000/年。总体而言，50 岁及以上年龄组的 PHPT 发病率（无论是否典型）明显增加（OR 1.023，95% CI 1.013-1.033）。此外，高钙血症和非典型 PHPT 女性多于男性。最后，典型 PHPT 患者的维生素 D 水平明显低于非典型 PHPT 患者：PHPT的高流行率和发病率应引起巴林和中东地区医生和临床实践的警觉，对典型和非典型PHPT进行常规检查，以控制和处理PHPT引起的并发症。不过，还需要在中东地区开展更多流行病学研究，以调查 PHPT 高发病率背后的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro endocrinology letters 医学-内分泌学与代谢

CiteScore

1.00

自引率

14.30%

发文量

审稿时长

6 months

期刊介绍： Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology Letters. Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered. The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.