Relationship between Respiratory Morbidity and Environmental Exposure to Organochlorine Pesticides in Armenia.

IF 2.4 Q1 Medicine

Journal of Health and Pollution Pub Date : 2021-08-17 eCollection Date: 2021-09-01 DOI:10.5696/2156-9614-11.31.210904

Natalya S Tadevosyan, Gayane V Kirakosyan, Susanna A Muradyan, Susanna B Poghosyan, Bavakan G Khachatryan

{"title":"Relationship between Respiratory Morbidity and Environmental Exposure to Organochlorine Pesticides in Armenia.","authors":"Natalya S Tadevosyan, Gayane V Kirakosyan, Susanna A Muradyan, Susanna B Poghosyan, Bavakan G Khachatryan","doi":"10.5696/2156-9614-11.31.210904","DOIUrl":null,"url":null,"abstract":"Background: Many studies have investigated the effects of organochlorine pesticides (OCPs) on adverse health outcomes. However, studies addressing the link between respiratory health and OCPs are limited. Organochlorine pesticides are stable compounds and belong to the class of endocrine disrupting chemicals that represent a threat to global health.Objectives: The aim of the present study was to examine the association between respiratory morbidity and environmental exposure to OCPs in selected regions in Armenia.Methods: The study was carried out in Lori and Gegharkunik provinces/marzes. The prevalence rate (per 100 000 population) and the average chronological indicators (ACh) for all respiratory diseases and asthma were calculated. Concentrations of OCPs (γ-hexachlorocyclohexane (γ-HCH), dichloro-diphenyl-trichloroethane [DDT], dichlorodiphenyldichloroethylene (DDE) and dichloro-diphenyl-dichloroethane (DDD)) were determined in soil and plant product samples and the average annual total concentration (AATC) of OCPs (γ-HCH + 4,4'-DDT + 4,4'-DDE+4,4'-DDD) was calculated.Results: The ACI for all respiratory diseases showed a growth tendency in areas of Gegharkunik province ranging from 14.2 to 20.9% and an increase in asthma ranging from 9.4% to 174.6%. The highest levels of AATC of OCPs were found in soil sampled in Gegharkunik province: 9.48 ± 1.11 μg/kg and 8.10 ± 1.05 μg/kg and these levels differed significantly from those in Lori (p=0.01-0.0007). The AATC of OCPs in plant products from Gegharkunik was also statistically higher: 1.83±0.13 μg/kg, in comparison with that of Lori province 1.31±0.09 μg/kg (p = 0.001 - 0.0000).Conclusions: The results indicate that the increased tendency of respiratory diseases and asthma could be related to OCP residues found in soil and plant products in Gegharkunik province. However, the role of OCPs should not be ignored. Further research is needed to study OCP contamination dynamics and clarify the role of OCPs in respiratory morbidity.Competing interests: The authors declare no competing financial interests.","PeriodicalId":52138,"journal":{"name":"Journal of Health and Pollution","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2021-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383794/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Health and Pollution","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5696/2156-9614-11.31.210904","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/9/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Many studies have investigated the effects of organochlorine pesticides (OCPs) on adverse health outcomes. However, studies addressing the link between respiratory health and OCPs are limited. Organochlorine pesticides are stable compounds and belong to the class of endocrine disrupting chemicals that represent a threat to global health.

Objectives: The aim of the present study was to examine the association between respiratory morbidity and environmental exposure to OCPs in selected regions in Armenia.

Methods: The study was carried out in Lori and Gegharkunik provinces/marzes. The prevalence rate (per 100 000 population) and the average chronological indicators (ACh) for all respiratory diseases and asthma were calculated. Concentrations of OCPs (γ-hexachlorocyclohexane (γ-HCH), dichloro-diphenyl-trichloroethane [DDT], dichlorodiphenyldichloroethylene (DDE) and dichloro-diphenyl-dichloroethane (DDD)) were determined in soil and plant product samples and the average annual total concentration (AATC) of OCPs (γ-HCH + 4,4'-DDT + 4,4'-DDE+4,4'-DDD) was calculated.

Results: The ACI for all respiratory diseases showed a growth tendency in areas of Gegharkunik province ranging from 14.2 to 20.9% and an increase in asthma ranging from 9.4% to 174.6%. The highest levels of AATC of OCPs were found in soil sampled in Gegharkunik province: 9.48 ± 1.11 μg/kg and 8.10 ± 1.05 μg/kg and these levels differed significantly from those in Lori (p=0.01-0.0007). The AATC of OCPs in plant products from Gegharkunik was also statistically higher: 1.83±0.13 μg/kg, in comparison with that of Lori province 1.31±0.09 μg/kg (p = 0.001 - 0.0000).

Conclusions: The results indicate that the increased tendency of respiratory diseases and asthma could be related to OCP residues found in soil and plant products in Gegharkunik province. However, the role of OCPs should not be ignored. Further research is needed to study OCP contamination dynamics and clarify the role of OCPs in respiratory morbidity.

Competing interests: The authors declare no competing financial interests.

Abstract Image

查看原文本刊更多论文

亚美尼亚呼吸系统发病率与环境中有机氯农药暴露之间的关系。

背景：许多研究调查了有机氯农药（OCPs）对不良健康后果的影响。然而，针对呼吸系统健康与有机氯农药之间联系的研究却很有限。有机氯农药是稳定化合物，属于内分泌干扰化学品，对全球健康构成威胁：本研究旨在考察亚美尼亚部分地区呼吸系统发病率与环境中暴露于有机氯农药之间的关系：研究在洛里省和盖加尔克尼克省/马兹进行。计算了所有呼吸道疾病和哮喘的发病率（每 100 000 人）和平均时序指标（ACh）。测定了土壤和植物产品样本中 OCPs（γ-六氯环己烷 (γ-HCH)、二氯二苯基三氯乙烷 [DDT]、二氯二苯基二氯乙烯 (DDE) 和二氯二苯基二氯乙烷 (DDD)）的浓度，并计算了 OCPs（γ-HCH + 4,4'-DDT + 4,4'-DDE+4,4'-DDD ）的年平均总浓度 (AATC)。结果显示盖加尔库尼克省所有呼吸道疾病的 ACI 均呈增长趋势，增幅在 14.2% 至 20.9% 之间，哮喘的增幅在 9.4% 至 174.6% 之间。在盖哈尔库尼克省采样的土壤中，OCPs 的 AATC 含量最高：9.48 ± 1.11 μg/kg 和 8.10 ± 1.05 μg/kg，这些含量与萝莉体内的含量有显著差异（p=0.01-0.0007）。格哈尔库尼克植物产品中 OCPs 的 AATC 在统计上也更高：1.83±0.13 μg/kg，而洛里省为 1.31±0.09 μg/kg（p = 0.001 - 0.0000）：结果表明，格哈尔库尼克省呼吸道疾病和哮喘发病率的增加可能与土壤和植物产品中的 OCP 残留有关。然而，OCP 的作用也不容忽视。需要进一步研究 OCP 的污染动态，明确 OCP 在呼吸道疾病中的作用：作者声明不存在经济利益冲突。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Health and Pollution Medicine-Public Health, Environmental and Occupational Health

自引率

0.00%

发文量

审稿时长

18 weeks

期刊介绍： The Journal of Health and Pollution (JH&P) was initiated with funding from the European Union and World Bank and continues to be a Platinum Open Access Journal. There are no publication or viewing charges. That is, there are no charges to readers or authors. Upon peer-review and acceptance, all articles are made available online. The high-ranking editorial board is comprised of active members who participate in JH&P submissions and editorial policies. The Journal of Health and Pollution welcomes manuscripts based on original research as well as findings from re-interpretation and examination of existing data. JH&P focuses on point source pollution, related health impacts, environmental control and remediation technology. JH&P also has an interest in ambient and indoor pollution. Pollutants of particular interest include heavy metals, pesticides, radionuclides, dioxins, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), air particulates (PM10 and PM2.5), and other severe and persistent toxins. JH&P emphasizes work relating directly to low and middle-income countries, however relevant work relating to high-income countries will be considered on a case-by-case basis.