Epigenetic marks in suicide: a review.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2021-10-01 DOI:10.1097/YPG.0000000000000297

Daniel F Ramos-Rosales, Fernando Vazquez-Alaniz, Norma Urtiz-Estrada, Eda G Ramirez-Valles, Edna M Mendez-Hernádez, Alma C Salas-Leal, Marcelo Barraza-Salas

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引用次数: 1

Abstract

Suicide is a complex phenomenon and a global public health problem that involves several biological factors that could contribute to the pathophysiology of suicide. There is evidence that epigenetic factors influence some psychiatric disorders, suggesting a predisposition to suicide or suicidal behavior. Here, we review studies of molecular mechanisms of suicide in an epigenetic perspective in the postmortem brain of suicide completers and peripheral blood cells of suicide attempters. Besides, we include studies of gene-specific DNA methylation, epigenome-wide association, histone modification, and interfering RNAs as epigenetic factors. This review provides an overview of the epigenetic mechanisms described in different biological systems related to suicide, contributing to an understanding of the genetic regulation in suicide. We conclude that epigenetic marks are potential biomarkers in suicide, and they could become attractive therapeutic targets due to their reversibility and importance in regulating gene expression.

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自杀的表观遗传学标记：综述。

自杀是一种复杂的现象，也是一个全球性的公共卫生问题，涉及几个可能导致自杀病理生理学的生物学因素。有证据表明，表观遗传因素会影响一些精神疾病，这表明有自杀或自杀行为的倾向。在此，我们从表观遗传学的角度回顾了自杀完成者死后大脑和自杀未遂者外周血细胞中自杀分子机制的研究。此外，我们还研究了基因特异性DNA甲基化、表观基因组广泛关联、组蛋白修饰和作为表观遗传因子的干扰RNA。这篇综述概述了与自杀相关的不同生物系统中描述的表观遗传学机制，有助于理解自杀中的基因调控。我们得出结论，表观遗传学标记是自杀的潜在生物标志物，由于其可逆性和在调节基因表达方面的重要性，它们可能成为有吸引力的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.