Impact of HIV-1 CRF55_01B infection on the evolution of CD4 count and plasma HIV RNA load in men who have sex with men prior to antiretroviral therapy.

IF 2.7 3区医学 Q3 VIROLOGY

Retrovirology Pub Date : 2021-08-16 DOI:10.1186/s12977-021-00567-z

Lan Wei, Hao Li, Xing Lv, Chenli Zheng, Guilian Li, Zhengrong Yang, Lin Chen, Xiaoxu Han, Huachun Zou, Yanxiao Gao, Jinquan Cheng, Hui Wang, Jin Zhao

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引用次数: 9

Abstract

Background: CRF55_01B is a newly identified HIV-1 circulating recombinant form originated from MSM in China. However, its impact on the disease progression and transmission risk has not been investigated. This study aimed to determine the impact of CRF55_01B infection on viral dynamics and immunological status so as to provide scientific evidence for further control and prevention effort on CRF55_01B. Linear mixed effect models were applied to evaluate CD4 cell count decline and viral load increase by subtype.

Results: Of the 3418 blood samples, 1446 (42.3%) were CRF07_BC, 1169 (34.2%) CRF01_AE, 467 (13.7%) CRF55_01B, 249 (7.3%) type B, and 87 (2.5%) other subtypes (CRF_08BC, CRF_01B, C). CRF55_01B had become the third predominant strain since 2012 in Shenzhen, China. CRF55_01B-infected MSM showed lower median of CD4 count than CRF07_BC-infected MSM (349.5 [IQR, 250.2-474.8] vs. 370.0 [IQR, 278.0-501.0], P < 0.05). CRF55_01B infection was associated with slower loss of CD4 count than CRF01_AE (13.6 vs. 23.3 [cells/µl]¹/²/year, P < 0.05)among MSM with initial CD4 count of 200-350 cells/µl. On the other hand, those infected with CRF55_01B showed higher median plasma HIV RNA load (5.4 [IQR, 5.0-5.9]) than both CRF01_AE (5.3 [IQR, 4.8-5.7], P < 0.05) and CRF07_BC (5.0 log10 [IQR, 4.5-5.5], P < 0.001) at the initiation of antiretroviral therapy. Furthermore, the annual increasing rate of viral load for CRF55_01B infection was significantly higher than that of CRF07_BC (2.0 vs. 0.7 log10 copies/ml/year, P < 0.01).

Conclusions: The relatively lower CD4 count and faster increase of plasma HIV RNA load of CRF55_01B-infected MSM without antiretroviral therapy suggest that CRF55_01B may lead to longer asymptomatic phase and higher risk of HIV transmission. Strengthened surveillance, tailored prevention strategies and interventions, and in-depth research focusing on CRF55_01B are urgently needed to forestall potential epidemic.

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HIV-1 CRF55_01B感染对抗逆转录病毒治疗前男男性行为者CD4计数和血浆HIV RNA载量演变的影响

背景:CRF55_01B是一种新发现的HIV-1循环重组形式，起源于中国的MSM。然而，其对疾病进展和传播风险的影响尚未调查。本研究旨在确定CRF55_01B感染对病毒动力学和免疫状态的影响，为CRF55_01B的进一步防控工作提供科学依据。采用线性混合效应模型评价CD4细胞计数下降和病毒载量增加的亚型。结果:3418份血样中，CRF07_BC 1446份(42.3%)，CRF01_AE 1169份(34.2%)，CRF55_01B 467份(13.7%)，B型249份(7.3%)，其他亚型(CRF_08BC、CRF_01B、C) 87份(2.5%)。2012年以来，CRF55_01B已成为深圳地区第三优势菌株。CRF55_01B感染的MSM CD4计数中位数低于crf07_bc感染的MSM (349.5 [IQR, 250.2-474.8] vs. 370.0 [IQR, 278.0-501.0]， P结论:未经抗逆转录病毒治疗的CRF55_01B感染的MSM CD4计数相对较低，血浆HIV RNA载量增加较快，提示CRF55_01B感染可能导致无症状期延长，HIV传播风险较高。为了预防潜在的流行病，迫切需要加强监测，制定针对性的预防战略和干预措施，并以CRF55_01B为重点进行深入研究。

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来源期刊

Retrovirology 医学-病毒学

CiteScore

5.80

自引率

3.00%

发文量

审稿时长

>0 weeks

期刊介绍： Retrovirology is an open access, online journal that publishes stringently peer-reviewed, high-impact articles on host-pathogen interactions, fundamental mechanisms of replication, immune defenses, animal models, and clinical science relating to retroviruses. Retroviruses are pleiotropically found in animals. Well-described examples include avian, murine and primate retroviruses. Two human retroviruses are especially important pathogens. These are the human immunodeficiency virus, HIV, and the human T-cell leukemia virus, HTLV. HIV causes AIDS while HTLV-1 is the etiological agent for adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. Retrovirology aims to cover comprehensively all aspects of human and animal retrovirus research.