Salivary markers and coronavirus disease 2019: insights from cross-talk between the oral microbiome and pulmonary and systemic low-grade inflammation and implications for vascular complications.
Antoine AbdelMassih, Alaa A Hassan, Aya S Abou-Zeid, Aya Hassan, Engy Hussein, Mahenar Gadalla, Mahinour Hussein, Maryam A Eid, Maryam Elahmady, Nadine El Nahhas, Nadine Emad, Nihal Zahra, Nour Aboushadi, Nourhan Ibrahim, Sherouk Mokhtar, Habiba-Allah Ismail, Nadine El-Husseiny, Reham Khaled Moharam, Esraa Menshawey, Rahma Menshawey
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引用次数: 1
Abstract
To date, coronavirus disease 2019 (COVID-19) has affected over 6.2 million individuals worldwide, including 1.46 million deaths. COVID-19 complications are mainly induced by low-grade inflammation-causing vascular degeneration. There is an increasing body of evidence that suggests that oral dysbiotic taxa are associated with worse prognosis in COVID-19 patients, especially the Prevotella genus, which was retrieved from nasopharyngeal and bronchoalveolar lavage samples in affected patients. Oral dysbiosis may act by increasing the likelihood of vascular complications through low-grade inflammation, as well as impairing respiratory mucosal barrier mechanisms against SARS-CoV-2. Salivary markers can be used to reflect this oral dysbiosis and its subsequent damaging effects on and the lungs and vasculature. Salivary sampling can be self-collected, and is less costly and less invasive, and thus may be a superior option to serum markers in risk stratification of COVID-19 patients. Prospective studies are needed to confirm such hypothesis. Video Abstract: http://links.lww.com/CAEN/A28.
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