Association of maternal intake of nitrate and risk of birth defects and preterm birth: a systematic review and dose-response meta-analysis.

IF 1.4 4区医学 Q4 ENVIRONMENTAL SCIENCES

Archives of Environmental & Occupational Health Pub Date : 2022-01-01 Epub Date: 2021-08-09 DOI:10.1080/19338244.2021.1953955

Nader Rahimi Kakavandi, Motahareh Hashemi Moosavi, Tayebeh Asadi, Morteza Abyadeh, Habib Yarizadeh, Ahmad Habibian Sezavar, Mohammad Abdollahi

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引用次数: 8

Abstract

In this study, the high versus low analysis method was applied to evaluate the association of maternal nitrate intake and risk of heart defect, limb deficiency, cleft lip, and preterm birth. Also, linear and non-linear dose-response associations between maternal intake of nitrate and risk of heart defects were investigated. In high versus low intake, the risk of heart defects in infants is directly associated with the level of nitrate exposure, but no significant relationship was found between the cleft lip, limb deficiency, and preterm birth. The linear dose-response meta-analysis was associated with risk of heart defects (RR: 1.03; 95% CI: 1.00 to 1.05, P = 0.400, I²= 0%, P heterogeneity= 0.602, n = 3) and nonlinear dose-response meta-analysis showed that maternal intake of nitrate higher than ∼4 mg/day is positively associated with heart defects risk (P non-linearity= 0.012).

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母亲摄入硝酸盐与出生缺陷和早产风险的关系:一项系统评价和剂量反应荟萃分析。

本研究采用高对低分析的方法来评估母亲硝酸盐摄入量与心脏缺陷、肢体缺陷、唇裂和早产风险的关系。此外，还研究了母体硝酸盐摄入量与心脏缺陷风险之间的线性和非线性剂量反应关系。在高摄入量和低摄入量中，婴儿心脏缺陷的风险与硝酸盐暴露水平直接相关，但在唇裂、肢体缺陷和早产之间没有发现显著的关系。线性剂量-反应荟萃分析与心脏缺陷风险相关(RR: 1.03;95% CI: 1.00 ~ 1.05, P = 0.400, I2= 0%， P异质性= 0.602,n = 3)，非线性剂量-反应荟萃分析显示，母体硝酸盐摄入量高于~ 4 mg/天与心脏缺陷风险呈正相关(P非线性= 0.012)。

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来源期刊

Archives of Environmental & Occupational Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： Archives of Environmental & Occupational Health , originally founded in 1919 as the Journal of Industrial Hygiene, and perhaps most well-known as the Archives of Environmental Health, reports, integrates, and consolidates the latest research, both nationally and internationally, from fields germane to environmental health, including epidemiology, toxicology, exposure assessment, modeling and biostatistics, risk science and biochemistry. Publishing new research based on the most rigorous methods and discussion to put this work in perspective for public health, public policy, and sustainability, the Archives addresses such topics of current concern as health significance of chemical exposure, toxic waste, new and old energy technologies, industrial processes, and the environmental causation of disease such as neurotoxicity, birth defects, cancer, and chronic degenerative diseases. For more than 90 years, this noted journal has provided objective documentation of the effects of environmental agents on human and, in some cases, animal populations and information of practical importance on which decisions are based.