Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder.

Fenglian Zheng, Yuxin Li, Zhizheng Zhuo, Yunyun Duan, Guanmei Cao, Decai Tian, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Xuemei Han, Sven Hallar, Frederik Barkhof, Yaou Liu
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引用次数: 7

Abstract

Background: Hippocampal involvement may differ between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD).

Objective: To investigate the morphometric, diffusion and functional alterations in hippocampus in MS and NMOSD and the clinical significance.

Methods: A total of 752 participants including 236 MS, 236 NMOSD and 280 healthy controls (HC) were included in this retrospective multi-center study. The hippocampus and subfield volumes, fractional anisotropy (FA) and mean diffusivity (MD), amplitude of low frequency fluctuation (ALFF) and degree centrality (DC) were analyzed, and their associations with clinical variables were investigated.

Results: The hippocampus showed significantly lower volume, FA and greater MD in MS compared to NMOSD and HC (p < 0.05), while no abnormal ALFF or DC was identified in any group. Hippocampal subfields were affected in both diseases, though subiculum, presubiculum and fimbria showed significantly lower volume only in MS (p < 0.05). Significant correlations between diffusion alterations, several subfield volumes and clinical variables were observed in both diseases, especially in MS (R = -0.444 to 0.498, p < 0.05). FA and MD showed fair discriminative power between MS and HC, NMOSD and HC (AUC > 0.7).

Conclusions: Hippocampal atrophy and diffusion abnormalities were identified in MS and NMOSD, partly explaining how clinical disability and cognitive impairment are differentially affected.

多发性硬化症和视神经脊髓炎频谱障碍的海马结构和功能改变。
背景:多发性硬化症(MS)和视神经脊髓炎频谱障碍(NMOSD)的海马受累可能不同。目的:探讨多发性硬化症和NMOSD大鼠海马形态、弥散和功能的改变及其临床意义。方法:回顾性多中心研究共纳入752例患者,其中MS 236例,NMOSD 236例,健康对照280例。分析海马和子场体积、分数各向异性(FA)和平均扩散率(MD)、低频波动幅度(ALFF)和度中心性(DC),并探讨其与临床变量的关系。结果:MS组海马体积、FA、MD均明显低于NMOSD组和HC组(p < 0.05), ALFF、DC均未见异常。两种疾病的海马亚区均受到影响,但只有MS的海底带、海底带前和海毛膜的体积显著降低(p < 0.05)。在这两种疾病中,弥散改变、几个子场体积和临床变量之间存在显著相关性,尤其是在MS中(R = -0.444 ~ 0.498, p < 0.05)。FA和MD在MS与HC、NMOSD与HC之间具有相当的判别能力(AUC > 0.7)。结论:在MS和NMOSD中发现海马萎缩和扩散异常,部分解释了临床残疾和认知功能障碍的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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