Lung Adenocarcinoma with Paraneoplastic Hyper-Eosinophilia Not Responding To Pembrolizumab.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-07-31 eCollection Date: 2021-01-01 DOI:10.1177/11795484211030164

Hisham Wehbe, Maria Kozah, Salwa A Koubaissi

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引用次数: 4

Abstract

Background: Paraneoplastic hyper-eosinophilia associated with metastatic lung adenocarcinoma is a rare finding and has been associated with a poor prognosis when present. Early hyper-eosinophilia appearing following non-small cell lung cancer (NSCLC) treatment with immune checkpoint inhibitors (ICI) has been previously reported with contradictory outcomes.

Case summary: We present the case of an elderly man with newly diagnosed metastatic lung adenocarcinoma and baseline hyper-eosinophilia, treated with pembrolizumab, and showing evidence of significant and rapid disease progression suggestive of hyper-progressive disease, worsening baseline hyper-eosinophilia, and a fatal outcome within 1 month of therapy initiation.

Conclusion: Pre-treatment hyper-eosinophilia could represent a predictive factor of an unfavorable response to ICI treatment in cases of NSCLC. Additional similar cases are needed to draw a more conclusive relationship.

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伴副肿瘤性嗜酸性粒细胞增多的肺腺癌对派姆单抗无反应。

背景:伴转移性肺腺癌的副肿瘤性嗜酸性细胞增多症是一种罕见的发现，出现时预后较差。免疫检查点抑制剂(ICI)治疗非小细胞肺癌(NSCLC)后出现的早期嗜酸性粒细胞增多症先前报道的结果相互矛盾。病例总结:我们报告了一例新诊断的转移性肺腺癌和基线嗜酸性粒细胞增多症的老年男性患者，接受派姆单抗治疗，并显示出明显和快速的疾病进展，提示疾病的超进展，基线嗜酸性粒细胞增多症恶化，并在治疗开始后1个月内死亡。结论:治疗前嗜酸性粒细胞增多可能是非小细胞肺癌对ICI治疗不良反应的一个预测因素。需要更多类似的案例来得出更确凿的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.