A Review of Principal Studies on the Development and Treatment of Epithelial Ovarian Cancer in the Laying Hen Gallus gallus.

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Comparative medicine Pub Date : 2021-08-01 Epub Date: 2021-07-29 DOI:10.30802/AALAS-CM-20-000116
Purab Pal, Kara Nicole Starkweather, Karen Held Hales, Dale Buchanan Hales
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引用次数: 3

Abstract

Often referred to as the silent killer, ovarian cancer is the most lethal gynecologic malignancy. This disease rarely shows any physical symptoms until late stages and no known biomarkers are available for early detection. Because ovarian cancer is rarely detected early, the physiology behind the initiation, progression, treatment, and prevention of this disease remains largely unclear. Over the past 2 decades, the laying hen has emerged as a model that naturally develops epithelial ovarian cancer that is both pathologically and histologically similar to that of the human form of the disease. Different molecular signatures found in human ovarian cancer have also been identified in chicken ovarian cancer including increased CA125 and elevated E-cadherin expression, among others. Chemoprevention studies conducted in this model have shown that decreased ovulation and inflammation are associated with decreased incidence of ovarian cancer development. The purpose of this article is to review the major studies performed in laying hen model of ovarian cancer and discuss how these studies shape our current understanding of the pathophysiology, prevention, and treatment of epithelial ovarian cancer.

蛋鸡上皮性卵巢癌发生及治疗的主要研究综述。
卵巢癌通常被称为沉默的杀手,是最致命的妇科恶性肿瘤。这种疾病很少表现出任何身体症状,直到晚期,没有已知的生物标志物可用于早期发现。由于卵巢癌很少被早期发现,这种疾病的发生、发展、治疗和预防背后的生理机制仍不清楚。在过去的20年里,蛋鸡已经成为自然发展上皮性卵巢癌的模型,在病理和组织学上都与人类形式的卵巢癌相似。在人类卵巢癌中发现的不同分子特征也在鸡卵巢癌中被发现,包括CA125增加和E-cadherin表达升高等。在该模型中进行的化学预防研究表明,排卵和炎症的减少与卵巢癌发病率的降低有关。本文的目的是回顾在蛋鸡卵巢癌模型中进行的主要研究,并讨论这些研究如何影响我们目前对上皮性卵巢癌的病理生理,预防和治疗的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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