Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health.

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2021-06-29 eCollection Date: 2021-07-01 DOI:10.15698/cst2021.07.253

Juan Zapata-Muñoz, Beatriz Villarejo-Zori, Pablo Largo-Barrientos, Patricia Boya

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引用次数: 0

Abstract

Autophagy is a critical cellular process by which biomolecules and cellular organelles are degraded in an orderly manner inside lysosomes. This process is particularly important in neurons: these post-mitotic cells cannot divide or be easily replaced and are therefore especially sensitive to the accumulation of toxic proteins and damaged organelles. Dysregulation of neuronal autophagy is well documented in a range of neurodegenerative diseases. However, growing evidence indicates that autophagy also critically contributes to neurodevelopmental cellular processes, including neurogenesis, maintenance of neural stem cell homeostasis, differentiation, metabolic reprogramming, and synaptic remodelling. These findings implicate autophagy in neurodevelopmental disorders. In this review we discuss the current understanding of the role of autophagy in neurodevelopment and neurodevelopmental disorders, as well as currently available tools and techniques that can be used to further investigate this association.

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更好地理解自噬在疾病和健康中对神经发育的作用。

自噬是一个关键的细胞过程，生物大分子和细胞器在溶酶体内有序降解。这一过程对神经元尤为重要：这些有丝分裂后的细胞不能分裂，也不容易被替换，因此对有毒蛋白质和受损细胞器的积累尤为敏感。在一系列神经退行性疾病中，神经元自噬功能失调已得到充分证实。然而，越来越多的证据表明，自噬对神经发育的细胞过程也有重要贡献，包括神经发生、神经干细胞平衡的维持、分化、代谢重编程和突触重塑。这些发现表明自噬与神经发育障碍有关。在这篇综述中，我们将讨论目前对自噬在神经发育和神经发育障碍中作用的理解，以及目前可用来进一步研究这种关联的工具和技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.