Seroprevalence of Hepatitis A and Hepatitis E Viruses among Pregnant Women in Northern Iran.

Q2 Medicine

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2021-07-02 eCollection Date: 2021-01-01 DOI:10.1155/2021/5130586

Farzin Sadeghi, Zahra Golchob, Maryam Javadian, Mohammad Barary, Parisa Sabbagh, Soheil Ebrahimpour, Masomeh Bayani

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引用次数: 2

Abstract

Background: Hepatitis A (HAV) and hepatitis E viruses (HEV) are endemic in Iran and are known major causes of acute viral hepatitis. Also, during pregnancy, they are associated with severe outcomes. Therefore, it is vital to evaluate the antibody levels against HAV and HEV in pregnant women to avoid severe outcomes incidence. Study design and methods. A total of 247 pregnant women were enrolled in this prospective cross-sectional study. In addition to completing the questionnaire and interviewing all participants, the serum samples were tested for anti-HAV and anti-HEV IgG using the enzyme-linked immunosorbent assay (ELISA). The association between anti-HAV and anti-HEV antibodies status and risk factors was evaluated.

Results: The mean age of patients was 28.06 ± 5.29 years. Anti-HAV antibody was found in 111 patients (44.9%), while anti-HEV antibody was detected in only two pregnant women (0.8%). The seroprevalence of HAV was inversely related to the level of education. There was no significant correlation between HAV antibody levels and age, marital status, residence location, and pregnancy trimesters.

Conclusion: Considering many complications of these diseases in pregnancy, the detection of enteroviral hepatitis, especially HAV in pregnant women, is necessary, and therefore, proactive measures, such as promoting education, improving people awareness, and vaccination, are recommended.

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伊朗北部孕妇中甲型肝炎和戊型肝炎病毒的血清患病率

背景:甲型肝炎(HAV)和戊型肝炎病毒(HEV)在伊朗流行，是已知的急性病毒性肝炎的主要原因。此外，在怀孕期间，它们与严重的后果有关。因此，评估孕妇抗甲肝病毒和戊肝病毒的抗体水平对于避免严重后果的发生至关重要。研究设计和方法。共有247名孕妇参加了这项前瞻性横断面研究。除了完成问卷调查和访谈所有参与者外，还使用酶联免疫吸附试验(ELISA)检测血清样本的抗甲型肝炎和抗hev IgG。评估抗hav和抗hev抗体状态与危险因素之间的关系。结果:患者平均年龄28.06±5.29岁。在111例(44.9%)患者中检测到抗hav抗体，而在2例(0.8%)孕妇中检测到抗hev抗体。甲肝血清患病率与受教育程度呈负相关。HAV抗体水平与年龄、婚姻状况、居住地、妊娠期无显著相关性。结论:考虑到这些疾病在妊娠期的许多并发症，检测肠道病毒性肝炎，特别是孕妇HAV是必要的，因此建议采取积极的措施，如宣传教育，提高人们的认识，接种疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Diseases in Obstetrics and Gynecology Medicine-Obstetrics and Gynecology

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Infectious Diseases in Obstetrics and Gynecology aims to disseminate new and important information to clinicians and other health care providers, scientists, and researchers involved in the study or treatment of infectious diseases, especially those affecting the female patient. Its ultimate aim is to advance knowledge and encourage research, thereby improving the prevention or diagnosis and treatment of patients affected by such diseases.