Dual-Energy Computed Tomography Proton-Dose Calculation with Scripting and Modified Hounsfield Units.

IF 2.1 Q3 ONCOLOGY
International Journal of Particle Therapy Pub Date : 2021-06-25 eCollection Date: 2021-01-01 DOI:10.14338/IJPT-20-00075.1
Anthony Kassaee, Chingyun Cheng, Lingshu Yin, Wei Zou, Taoran Li, Alexander Lin, Samuel Swisher-McClure, John N Lukens, Robert A Lustig, Shannon O'Reilly, Lei Dong, Roni Hytonen Ms, Boon-Keng Kevin Teo
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引用次数: 5

Abstract

Purpose: To describe an implementation of dual-energy computed tomography (DECT) for calculation of proton stopping-power ratios (SPRs) in a commercial treatment-planning system. The process for validation and the workflow for safe deployment of DECT is described, using single-energy computed tomography (SECT) as a safety check for DECT dose calculation.

Materials and methods: The DECT images were acquired at 80 kVp and 140 kVp and were processed with computed tomography scanner software to derive the electron density and effective atomic number images. Reference SPRs of tissue-equivalent plugs from Gammex (Middleton, Wisconsin) and CIRS (Computerized Imaging Reference Systems, Norfolk, Virginia) electron density phantoms were used for validation and comparison of SECT versus DECT calculated through the Eclipse treatment planning system (Varian Medical Systems, Palo Alto, California) application programming interface scripting tool. An in-house software was also used to create DECT SPR computed tomography images for comparison with the script output. In the workflow, using the Eclipse system application programming interface script, clinical plans were optimized with the SECT image set and then forward-calculated with the DECT SPR for the final dose distribution. In a second workflow, the plans were optimized using DECT SPR with reduced range-uncertainty margins.

Results: For the Gammex phantom, the root mean square error in SPR was 1.08% for DECT versus 2.29% for SECT for 10 tissue-surrogates, excluding the lung. For the CIRS Phantom, the corresponding results were 0.74% and 2.27%. When evaluating the head and neck plan, DECT optimization with 2% range-uncertainty margins achieved a small reduction in organ-at-risk doses compared with that of SECT plans with 3.5% range-uncertainty margins. For the liver case, DECT was used to identify and correct the lipiodol SPR in the SECT plan.

Conclusion: It is feasible to use DECT for proton-dose calculation in a commercial treatment planning system in a safe manner. The range margins can be reduced to 2% in some sites, including the head and neck.

Abstract Image

Abstract Image

Abstract Image

用脚本和改进的Hounsfield单位计算双能计算机断层扫描质子剂量。
目的:描述双能量计算机断层扫描(DECT)在商业治疗计划系统中用于计算质子停止功率比(SPRs)的实现。本文描述了DECT的验证过程和安全部署工作流程,使用单能量计算机断层扫描(SECT)作为DECT剂量计算的安全检查。材料和方法:分别在80 kVp和140 kVp下获取DECT图像,用计算机断层扫描软件进行处理,得到电子密度和有效原子序数图像。使用Gammex (Middleton, Wisconsin)和CIRS(电脑化成像参考系统,Norfolk, Virginia)电子密度模型的组织等效塞的参考spr,通过Eclipse治疗计划系统(Varian Medical Systems, Palo Alto, California)应用程序编程接口脚本工具计算,验证和比较SECT与DECT。还使用内部软件创建DECT SPR计算机断层扫描图像,以便与脚本输出进行比较。在工作流程中,使用Eclipse系统应用程序编程接口脚本,利用SECT图像集对临床计划进行优化,然后利用DECT SPR对最终剂量分布进行前向计算。在第二个工作流程中,使用DECT SPR优化了计划,减少了范围不确定性。结果:对于Gammex假体,10个组织替代物(不包括肺),DECT的SPR均方根误差为1.08%,而SECT的SPR均方根误差为2.29%。对于CIRS幻影,相应的结果分别为0.74%和2.27%。在评估头颈部计划时,与范围不确定度为3.5%的SECT计划相比,2%范围不确定度的DECT优化实现了器官危险剂量的小幅减少。对于肝脏病例,DECT用于识别和纠正SECT计划中的脂醇SPR。结论:在商业化的治疗计划系统中使用DECT进行质子剂量计算是可行的,且安全可行。在某些部位,包括头部和颈部,范围边界可以减少到2%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Particle Therapy
International Journal of Particle Therapy Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
3.70
自引率
5.90%
发文量
23
审稿时长
20 weeks
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