Relationship between circulating insulin-like growth factor-1 and blood pressure in adults: A systematic review and meta-analysis of observational studies

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2021-10-01 DOI:10.1016/j.ghir.2021.101416

Lina Leng , Yuling Xing , Yi Liang , Chang Wang , Huijuan Ma

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引用次数: 1

Abstract

Objective

Insulin-like growth factor 1 (IGF-1) is an important factor related to cardiovascular disease. In recent years, studies have shown the involvement of IGF-1 and blood pressure (BP). Nevertheless, the results were inconsistent. Thus, the purpose of this study was to systematically evaluate the associations of circulating IGF-1 levels with BP in adults.

Methods

Two reviewers independently searched and screened articles from the Pubmed, EMBASE, Cochrane Library, CNKI, and WANFANG databases up to May 2020. A total of 12 studies that reported the correlation coefficients between IGF-1, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were included.

Results

IGF-1 was significantly correlated with SBP [r = −0.15; 95% CI = −0.21, −0.08; P < 0.0001] and DBP [r = −0.10; 95% CI = −0.16, −0.05; P = 0.0004]. Subgroup analysis further revealed that the relationship between IGF-1 and BP was influenced by race and age.

Conclusion

Circulating IGF-1 was negatively correlated with SBP and DBP. Further researches are necessary to explore the pathogenesis of this relationship and to evaluate the role of IGF-1 in the treatment of hypertension.

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成人循环胰岛素样生长因子-1与血压的关系:观察性研究的系统回顾和荟萃分析

目的胰岛素样生长因子1 (IGF-1)是心血管疾病的重要相关因子。近年来，研究表明IGF-1与血压(BP)有关。然而，结果并不一致。因此，本研究的目的是系统地评估成人血液中IGF-1水平与血压的关系。方法两名审稿人独立检索并筛选了截至2020年5月的Pubmed、EMBASE、Cochrane Library、CNKI和万方数据库中的文章。共有12项研究报告了IGF-1与收缩压(SBP)和舒张压(DBP)之间的相关系数。结果igf -1与收缩压呈显著相关[r = - 0.15;95% ci = - 0.21， - 0.08;P & lt;0.0001]和DBP [r =−0.10;95% ci =−0.16，−0.05;p = 0.0004]。亚组分析进一步发现IGF-1与BP的关系受种族和年龄的影响。结论循环IGF-1与收缩压、舒张压呈负相关。这一关系的发病机制以及IGF-1在高血压治疗中的作用有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.