Ivan M Lengyel, Daniele Soroldoni, Andrew C Oates, Luis G Morelli
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引用次数: 0
Abstract
We study the effects of multiple binding sites in the promoter of a genetic oscillator. We evaluate the regulatory function of a promoter with multiple binding sites in the absence of cooperative binding, and consider different hypotheses for how the number of bound repressors affects transcription rate. Effective Hill exponents of the resulting regulatory functions reveal an increase in the nonlinearity of the feedback with the number of binding sites. We identify optimal configurations that maximize the nonlinearity of the feedback. We use a generic model of a biochemical oscillator to show that this increased nonlinearity is reflected in enhanced oscillations, with larger amplitudes over wider oscillatory ranges. Although the study is motivated by genetic oscillations in the zebrafish segmentation clock, our findings may reveal a general principle for gene regulation.
期刊介绍：
Papers in Physics publishes original research in all areas of physics and its interface with other subjects. The scope includes, but is not limited to, physics of particles and fields, condensed matter, relativity and gravitation, nuclear physics, physics of fluids, biophysics, econophysics, chemical physics, statistical mechanics, soft condensed matter, materials science, mathematical physics and general physics. Contributions in the areas of foundations of physics, history of physics and physics education are not considered for publication. Articles published in Papers in Physics contain substantial new results and ideas that advance the state of physics in a non-trivial way. Articles are strictly reviewed by specialists prior to publication. Papers in Physics highlights outstanding articles published in the journal through the Editors'' choice section. Papers in Physics offers two distinct editorial treatments to articles from which authors can choose. In Traditional Review, manuscripts are submitted to anonymous reviewers seeking constructive criticism and editors make a decision on whether publication is appropriate. In Open Review, manuscripts are sent to reviewers. If the paper is considered original and technically sound, the article, the reviewer''s comments and the author''s reply are published alongside the names of all involved. This way, Papers in Physics promotes the open discussion of controversies among specialists that are of help to the reader and to the transparency of the editorial process. Moreover, our reviewers receive their due recognition by publishing a recorded citable report. Papers in Physics publishes Commentaries from the reviewer(s) if major disagreements remain after exchange with the authors or if a different insight proposed is considered valuable for the readers.
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