The association between Helicobacter pylori and obesity: a systematic review and meta-analysis of case-control studies.

Ali Baradaran, Hojat Dehghanbanadaki, Sara Naderpour, Leila Mohammadi Pirkashani, Abdolhalim Rajabi, Roya Rashti, Sevda Riahifar, Yousef Moradi
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引用次数: 0

Abstract

Introduction: The relationship between H. pylori infection and obesity development has remained controversial among various studies. The aim of this study was to clarify the pooled effect of H. pylori infection on the development of obesity and vice versa.

Methods: We searched international databases including Medline (PubMed), Web of sciences, Scopus, EMBASE, Cochrane, Ovid, and CINHAL to retrieve all case-control studies reporting the effect of H. pylori on obesity and vice versa, which had been published in English between January 1990 and June 2019. The quality of included studies was assessed by the Modified Newcastle-Ottawa Scale for Case-Control studies. The logarithm of the odds ratio (OR) and its standard error was used for the meta-analysis.

Results: Eight case-control studies with 25,519 participants were included for qualitative and quantitative analyses. The pooled analysis showed that obese participants had a higher risk of H. pylori infection than lean participants with an odds ratio of 1.46 (95%CI: 1.26, 1.68). Also, the pooled analysis revealed that participants infected by H. pylori had a higher risk of obesity than non-infected participants with an odds ratio of 1.01 (95%CI: 1.01, 1.02).

Conclusion: The results of this meta-analysis showed that there was a positive correlation between the risk of H. pylori infection and the prevalence of obesity development. Thus, H. pylori positive patients were more likely to be obese, and obese individuals had higher risks of H. pylori infection.

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幽门螺杆菌与肥胖的关系:病例对照研究的系统回顾和荟萃分析。
导言:幽门螺杆菌感染与肥胖发展之间的关系在各种研究中一直存在争议。本研究旨在明确幽门螺杆菌感染对肥胖发展的综合影响,反之亦然:我们检索了包括 Medline (PubMed)、Web of sciences、Scopus、EMBASE、Cochrane、Ovid 和 CINHAL 在内的国际数据库,检索了 1990 年 1 月至 2019 年 6 月间用英文发表的所有报道幽门螺杆菌对肥胖及其影响的病例对照研究。纳入研究的质量采用修改后的纽卡斯尔-渥太华病例对照研究量表进行评估。荟萃分析采用的是几率比(OR)的对数及其标准误差:结果:共纳入了 8 项病例对照研究,对 25 519 名参与者进行了定性和定量分析。汇总分析表明,肥胖者感染幽门螺杆菌的风险高于瘦者,几率比为 1.46(95%CI:1.26,1.68)。此外,汇总分析还显示,感染幽门螺杆菌的参与者比未感染幽门螺杆菌的参与者有更高的肥胖风险,几率比为 1.01(95%CI:1.01,1.02):这项荟萃分析的结果表明,幽门螺杆菌感染风险与肥胖发病率之间存在正相关。因此,幽门螺杆菌阳性患者更容易肥胖,而肥胖者感染幽门螺杆菌的风险更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
7
审稿时长
8 weeks
期刊介绍: Clinical Diabetes and Endocrinology is an open access journal publishing within the field of diabetes and endocrine disease. The journal aims to provide a widely available resource for people working within the field of diabetes and endocrinology, in order to improve the care of people affected by these conditions. The audience includes, but is not limited to, physicians, researchers, nurses, nutritionists, pharmacists, podiatrists, psychologists, epidemiologists, exercise physiologists and health care researchers. Research articles include patient-based research (clinical trials, clinical studies, and others), translational research (translation of basic science to clinical practice, translation of clinical practice to policy and others), as well as epidemiology and health care research. Clinical articles include case reports, case seminars, consensus statements, clinical practice guidelines and evidence-based medicine. Only articles considered to contribute new knowledge to the field will be considered for publication.
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