Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report.

Allergologie Select Pub Date : 2021-06-18 eCollection Date: 2021-01-01 DOI:10.5414/ALS400537

Miguel Mayo-Yáñez, Andrea Díaz-Díaz, Juan C Vázquez-Barro, Jesús Herranz González-Botas, Angélica Figueroa, Carlos S Martín-Martín

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Abstract

Aim: To analyze the diamine oxidase (DAO), the main catabolic enzyme of histamine, degradation activity and its relation with symptoms of persistent allergic rhinitis.

Methods: In this descriptive and analytical observational study, we collected DAO activity levels and the nasal peak inspiratory flow.

Results: Enzymatic activity deficit in 108 patients was 46.3% (95% CI, 0.44 - 0.63), 33.33% in mild and 47.92% in moderate/severe rhinitis (p = 0.376). The nasal peak inspiratory flow in patients with a deficit in DAO activity was 76.30 ± 28.40 L/min compared to 93.62 ± 37.50 L/min in patients with normal enzymatic activity (p = 0.010).

Conclusions: It seems that the lower the catabolic activity of DAO, the lower the nasal peak inspiratory flow observed. Although DAO activity levels could be a severity biomarker in allergic rhinitis, a cause-effect association cannot be concluded. The enzyme could be another actor in the pathophysiology of allergic rhinitis.

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过敏性鼻炎与二胺氧化酶活性之间的关系：初步报告。

目的：分析组胺的主要分解酶二胺氧化酶（DAO）的降解活性及其与持续性过敏性鼻炎症状的关系：在这项描述性和分析性观察研究中，我们收集了 DAO 活性水平和鼻腔吸气流量峰值：结果：108 名患者的酶活性缺失率为 46.3%（95% CI，0.44 - 0.63），轻度鼻炎患者为 33.33%，中度/重度鼻炎患者为 47.92%（P = 0.376）。DAO活性不足患者的鼻腔吸气流量峰值为76.30 ± 28.40 L/min，而酶活性正常患者的鼻腔吸气流量峰值为93.62 ± 37.50 L/min（p = 0.010）：看来，DAO 的分解活性越低，鼻腔吸气流量峰值就越低。尽管 DAO 活性水平可能是过敏性鼻炎严重程度的生物标志物，但并不能得出因果关系的结论。该酶可能是过敏性鼻炎病理生理学中的另一个角色。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Allergologie Select

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