Protective Effect of Capparis spinosa Extract against Focal Cerebral Ischemia-reperfusion Injury in Rats.

Q3 Psychology

Central nervous system agents in medicinal chemistry Pub Date : 2021-01-01 DOI:10.2174/1871524921666210625112356

Hassan Rakhshandeh, Samira Asgharzade, Mohammad Bagher Khorrami, Fatemeh Forouzanfar

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引用次数: 9

Abstract

Background: Ischemic stroke is a serious public health problem. Despite extensive researches focusing on the area, little is known about novel treatments.

Objective: In this study, we aimed to investigate the effects of Capparis spinosa (C. spinosa) extract in the middle cerebral artery occlusion (MCAO) model of ischemic stroke.

Methods: Wistar rats underwent 30-min MCAO-induced brain ischemia followed by 24 h of reperfusion. C. spinose was administrated orally once a day for 7 days before the induction of MCAO. The neurologic outcome, infarct volume (TTC staining), histological examination, and markers of oxidative stress, including total thiol content, and malondialdehyde (MDA) levels, were measured 24hr. after the termination of MCAO.

Results: Pretreatment with C. spinosa reduced neurological deficit score, histopathological alterations, and infarct volume in treated groups compared to the stroke group. Furthermore, pretreatment with C. spinosa extract significantly reduced the level of MDA with concomitant increases in the levels of thiol in the brain tissues compared to the stroke group.

Conclusion: Our study demonstrates that C. spinosa extract effectively protects MCAO injury through the attenuation or the suppression of the oxidative stress.

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荆芥提取物对大鼠局灶性脑缺血再灌注损伤的保护作用。

背景:缺血性脑卒中是一个严重的公共卫生问题。尽管对该领域进行了广泛的研究，但人们对新的治疗方法知之甚少。目的:探讨刺毛柑提取物对缺血性脑卒中大脑中动脉闭塞(MCAO)模型的影响。方法:Wistar大鼠脑缺血30min，再灌注24h。诱导MCAO前7天，每日口服1次。24小时测量神经系统预后、梗死面积(TTC染色)、组织学检查和氧化应激标志物，包括总硫醇含量和丙二醛(MDA)水平。在澳门民航总局终止后。结果:与脑卒中组相比，脊髓棘草预处理降低了治疗组的神经功能缺损评分、组织病理学改变和梗死体积。此外，与中风组相比，棘草提取物预处理显著降低了MDA水平，同时脑组织中硫醇水平升高。结论:本研究表明棘草提取物通过抑制或抑制氧化应激对MCAO损伤有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.